A Cross-sectional Study on the Association of Peptidoglycan Fragments Derived From Gut Microbiota With Colorectal Cancer

NCT ID: NCT06379412

Last Updated: 2024-04-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-07-01

Study Completion Date

2024-12-31

Brief Summary

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The goal of this observational study is to explore the association of peptidoglycan fragments derived from gut microbiota with colorectal cancer (CRC). The main question it aims to answer is: Are peptidoglycan fragments from the gut microbiota associated with the progression of colorectal cancer? Participants will provide biological specimens (blood, feces, colon tissue obtained during surgery)

Detailed Description

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To explore whether peptidoglycan fragments can be used as screening or diagnostic indicators for colorectal cancer

Conditions

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Colorectal Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Colorectal Cancer(CRC)

People who are diagnosed with CRC by colonoscopy and pathological biopsy

observational study, no intervention

Intervention Type OTHER

observational study, no intervention

Colorectal adenoma(CRA)

People who are diagnosed with CRA by colonoscopy and pathological biopsy

observational study, no intervention

Intervention Type OTHER

observational study, no intervention

Colorectal polyp(CRP)

People who are diagnosed with CRP by colonoscopy and pathological biopsy

observational study, no intervention

Intervention Type OTHER

observational study, no intervention

Healthy

People who have no obvious abnormality in the whole colon

observational study, no intervention

Intervention Type OTHER

observational study, no intervention

Interventions

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observational study, no intervention

observational study, no intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* People who underwent total colonoscopy in gastroenteroscopy room.
* People who agree to participate in this study and are willing to sign informed consent.

Exclusion Criteria

* Previous diagnosis of malignant tumors other than colorectal cancer.
* Received any of the following drug treatments within 1 month before sample collection: ① Drugs used for the treatment of colorectal diseases; ② Antibiotics; ③probiotics; ④ Laxatives.
* Patients with a family history of colorectal cancer.
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Zhujiang Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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He Xiaolong, Professor

Role: STUDY_DIRECTOR

Southern Medical University, China

Locations

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Zhujiang Hospital of Southern Medical University

Guangzhou, Guangdong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Hu Mengyao

Role: CONTACT

1587088392

Facility Contacts

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He Xiaolong, Professor

Role: primary

186 2007 1640

Other Identifiers

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Zhujianghmy

Identifier Type: -

Identifier Source: org_study_id

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