The Relationship Between Postoperative Changes of Oral and Intestinal Flora and Prognosis
NCT ID: NCT03667495
Last Updated: 2018-09-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2017-11-01
2021-03-01
Brief Summary
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Detailed Description
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The human colon plays host to a diverse and metabolically complex community of microorganisms. While the specific oral microbiome has been found to contribute to the development of colorectal cancer. Investigators speculate that specific oral microbiota related to colorectal cancer relapse after curative treatment.
Patients are routinely offered surveillance in order to detect disease recurrence at an early, asymptomatic stage, with the intention of improving survival. Nevertheless, controversy continues to surround the optimal surveillance protocols. Investigators aim to discover if any difference of oral microbiota is exist in patients who suffer from relapse compared with patients who do not.
Future surveillance after colorectal cancer treatment should focus on risk-stratification. Finally investigators will develop patient-centred programmes of surveillance protocols base on microbiota analysis.
Conditions
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Study Design
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OTHER
PROSPECTIVE
Study Groups
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Relapse
Patients who suffered colorectal cancer or adenoma relapse after curative surgery
No interventions assigned to this group
Remission
Patients who get remission after curative surgery
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Patients who underwent exhaustive colorectal cancer surgical resection and accept colonoscopy
* Patients between the age of 35 and 75 years old without considering sex
* Patients with BMI= 18.5-23.9
* Participants can follow the visit plan
Exclusion Criteria
* Chronic renal diseases and hepatic cirrhosis
* Chronic ischemic heart disease with unstable angina, chronic heart failure at class III or IV and acute myocardial infarction in the last 6 months
* Individuals with a history of Chronic diarrhea
* Individuals with a history of Diabetes mellitus
* Individuals with a history of Hypertension
* Individuals with a history of autoimmune diseases
* Use of antibiotics and probiotics 3 mouth before samples collection
* Individuals with a history of abdominal operation due to any reason
* Individuals with any history of cancer other than colorectal cancer
* Individuals with Inflammatory bowel disease
18 Years
80 Years
ALL
No
Sponsors
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First Affiliated Hospital of Harbin Medical University
OTHER
Responsible Party
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Principal Investigators
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Yunwei Wei
Role: STUDY_DIRECTOR
First Affiliated Hospital of Harbin Medical University
Locations
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Yunwei Wei
Harbin, Heilongjiang, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Yunwei Wei 2018-09-04
Identifier Type: -
Identifier Source: org_study_id
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