Predictors of Disease Recurrence After Curative Surgery for Stage I Colon Cancer
NCT ID: NCT05726188
Last Updated: 2023-07-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
2000 participants
OBSERVATIONAL
2022-04-01
2023-09-30
Brief Summary
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The present multicentric retrospective study aims to:
1. Assess the actual incidence of recurrence in a large cohort of patients with stage I CC undergone curative resection.
2. Investigate the clinical and pathological characteristics of patients who developed a recurrence, with the aim of identifying those associated with a significantly increased risk.
3. Analyze the pattern of recurrence.
4. Analyze survival after recurrence.
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Stage I colon cancer
Patients aged 18 years or above with pT1 or pT2 N0 colon cancer (up to the recto-sigmoid junction) who underwent curative resection between January 2010 and December 2019
Colonic resection
Elective or urgent colonic resection; minimally-invasive or open surgery; completion surgery for endoscopically resected pT1 colon cancer with high risk features
Interventions
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Colonic resection
Elective or urgent colonic resection; minimally-invasive or open surgery; completion surgery for endoscopically resected pT1 colon cancer with high risk features
Eligibility Criteria
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Inclusion Criteria
* Colon cancer up to recto-sigmoid junction
* Histological diagnosis of adenocarcinoma
* pT1 or pT2 according to AJCC staging system
* Urgent and elective surgery
* Curative resection
* Minimally invasive or open surgery
* Completion surgery included (Surgery for endoscopically resected pT1)
Exclusion Criteria
* Adenoma with low- or high-grade dysplasia
* Histology other than adenocarcinoma (i.e., lymphoma, neuroendocrine tumor, squamous carcinoma, etc)
* Neo-adjuvant chemotherapy or radiotherapy
* History of tumors other than CC
18 Years
ALL
No
Sponsors
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Azienda Ospedaliera Universitaria Integrata Verona
OTHER
Responsible Party
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Locations
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Unit of Digestive and HPB Surgery, Henri Mordor University Hospital
Paris, , France
Chirurgia dell'Apparato Digerente, IRCSS Giovanni Paolo II
Bari, , Italy
Chirurgia Generale e Trapianto di Fegato, Azienda Ospedaliera Consorziale Policlinico di Bari
Bari, , Italy
UO Chirurgia Generale 3, Spedali Civili 1
Brescia, , Italy
Chirurgia Coloproctologica, AOU Cagliari
Cagliari, , Italy
Chirurgia Generale, Ospedale di Cles
Cles, , Italy
Chirurgia 1, Ospedale di Cona, AOUI Ferrara
Cona, , Italy
Chirurgia Generale Colorettale, Ospedale degli Infermi
Faenza, , Italy
UOS Chirurgia Colo-rettale, Ospedale San Gerardo
Monza, , Italy
Chirurgia Endoscopica, AOUI Federico II
Napoli, , Italy
UOC Oncologia Chirurgia Colorettale, Istituto Nazionale Tumori - IRCCS Fondazione Pascale
Napoli, , Italy
Chirurgia Generale, AOU San Luigi Gonzaga
Orbassano, , Italy
Chirurgia Generale 3, AOUI Padova
Padua, , Italy
ASL TO 3 Presidio Pinerolo, Chirurgia
Pinerolo, , Italy
Chirurgia Generale 2, Policlinico Gemelli
Roma, , Italy
Policlinico TOR Vergata, Roma, Chirurgia Mininvasiva e dell'Apparato Digerente
Roma, , Italy
UOC Chirurgia Generale 1, Policlinico Gemelli
Roma, , Italy
Chirurgia Generale, Ospedale Santa Maria della Misericordia
Rovigo, , Italy
Chirurgia Colorettale, IRCCS Humanitas
Rozzano, , Italy
Chirurgia d'Urgenza e PS 3, AOU Città della Salute e della Scienza
Torino, , Italy
Chirurgia Generale e Mininvasiva, Ospedale San Camillo
Trento, , Italy
SC Clinica Chirurgia, Azienda Sanitaria Universitaria Giuliano Isontina
Trieste, , Italy
Unità di Chirurgia Colorettale, Clinica Santa Rita
Vercelli, , Italy
Chirurgia Generale ed Epatobiliare, AOUI Verona
Verona, , Italy
Countries
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Central Contacts
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Facility Contacts
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Nicola De Angelis
Role: primary
Michele Simone
Role: primary
Donato Francesco Altomare
Role: primary
Riccardo Nascimbeni
Role: primary
Luigi Zorcolo
Role: primary
Ciarleglio Francesco
Role: primary
Gabriele Anania
Role: primary
Isacco Montroni
Role: primary
Marco Braga
Role: primary
Marco Milone
Role: primary
Delrio Paolo
Role: primary
Maurizio Degiuli
Role: primary
Salvatore Pucciarelli
Role: primary
Andrea Muratore
Role: primary
Claudio Coco
Role: primary
Roberto Persiani
Role: primary
Maurizio De Luca
Role: primary
Antonino Spinelli
Role: primary
Mauro Santarelli
Role: primary
Alberto Di Leo
Role: primary
Nicolò de Manzini
Role: primary
Mario Trompetto
Role: primary
Other Identifiers
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CORE1
Identifier Type: -
Identifier Source: org_study_id
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