Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
127052 participants
OBSERVATIONAL
2024-07-30
2025-02-20
Brief Summary
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Detailed Description
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In this retrospective cohort study, the investigators aimed to evaluate the association between preoperative serum uric acid levels and postoperative acute kidney injury in female patients undergoing non-cardiac surgery, with a particular focus on menopausal status. Women were stratified into premenopausal and postmenopausal groups based on age and clinical criteria. The investigators hypothesized that the threshold and pattern of serum uric acid-associated acute kidney injury risk may differ between these two populations due to differences in hormonal status and baseline renal reserve.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Premenopausal Women
No Intervention: Observational Cohort
This observational cohort includes female patients undergoing non-cardiac surgery. No intervention was administered as part of the study protocol. Preoperative serum uric acid levels were measured, and patients were followed for the development of postoperative acute kidney injury. Data were analyzed retrospectively to assess the association between uric acid levels and acute kidney injury, with subgroup analyses based on menopausal status (premenopausal vs. postmenopausal women).
Postmenopausal Women
No Intervention: Observational Cohort
This observational cohort includes female patients undergoing non-cardiac surgery. No intervention was administered as part of the study protocol. Preoperative serum uric acid levels were measured, and patients were followed for the development of postoperative acute kidney injury. Data were analyzed retrospectively to assess the association between uric acid levels and acute kidney injury, with subgroup analyses based on menopausal status (premenopausal vs. postmenopausal women).
Interventions
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No Intervention: Observational Cohort
This observational cohort includes female patients undergoing non-cardiac surgery. No intervention was administered as part of the study protocol. Preoperative serum uric acid levels were measured, and patients were followed for the development of postoperative acute kidney injury. Data were analyzed retrospectively to assess the association between uric acid levels and acute kidney injury, with subgroup analyses based on menopausal status (premenopausal vs. postmenopausal women).
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Patients who underwent nephrectomy or kidney transplantation (either as recipients or donors)
* Patients diagnosed with chronic kidney disease or who had already undergone kidney replacement therapy
* Patients with estimated glomerular filtration rate \< 30 mL/min/1.73m²; and patients with incomplete data or missing laboratory values
18 Years
FEMALE
No
Sponsors
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Asan Medical Center
OTHER
Responsible Party
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Ji-Hoon Sim
Assistant Professor
Locations
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Asan Medical Center
Seoul, Songpa, South Korea
Countries
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Other Identifiers
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AMC [2024-1090]
Identifier Type: -
Identifier Source: org_study_id
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