Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Diabetic Kidney Injury in Type 2 Diabetes

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-06-30

Study Completion Date

2024-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

An prospective observetional study to asses the predictive value of serum uric acid to high density lipoprotein cholesterol ratio for diabetic kidney injury in type 2 diabetes

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Triglyceride/High-density Lipoprotein Cholesterol Ratio in Chronic Kidney Disease

NCT02113462

Chronic Kidney Disease

COMPLETED

Hyperuricemia as Early Indication of CKD Progressing in Prediabetic

NCT07199205

CKD Progression

NOT_YET_RECRUITING

High Neutrophil-to-Lymphocyte Ratio and Patients With Hemodialysis

NCT07070557

Hemodialysis Patient

NOT_YET_RECRUITING

Renal Resisitive Index as an Indicator of the Progression of Diabetic Nephropathy

NCT03658317

Diabetic Nephropathy

UNKNOWN NA

Roles of Uremic Toxins in Uremic Sacropenia

NCT03060590

Sarcopenia

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Diabetic Kidney Injury (DKI) is a serious microvascular complication of diabetes mellitus occuring in about 20 % to 50% of diabetic patients and is the single commonest cause of ESRD.DKI is asociated with arterial HTN and increased cardiovascular morbidity and mortality. outcomes for both type 1 DM and type 2 DM who develop DKI are significantly worse than who do not .Serum uric acid was reported to be asociated with inflamatory and metabolic diseases such as metabolic syndrome , type 2 DM,thyroiditis and NAFLD while HDL-cholesterol decreased the odds of developing DKI by 20%.It is generally accepted that hyperuricemia and low HDL-c were considered to be a risk factor of other indicators for development of DKI.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Diabetic Kidney Injury

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CROSSOVER

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

HbA1c level group

* well controlled diabetic group : HBA1c less than 7%
* poorly controlled diabetic group : HBA1c equal to ore more than 7%

serum uric acid level to plasma HDL-c level ratio (UHR)

Intervention Type DIAGNOSTIC_TEST

high UHR is considered to be a risk factor for development of DKI in type 2 DM

UHR level group

median levels of UHR will be used to dichotomize the patients into groups of :

* low UHR group
* high UHR group

serum uric acid level to plasma HDL-c level ratio (UHR)

Intervention Type DIAGNOSTIC_TEST

high UHR is considered to be a risk factor for development of DKI in type 2 DM

DKI group

study population will be grouped into another two groups according to the presence of DKI:

* patients with DKI
* patients without DKI

serum uric acid level to plasma HDL-c level ratio (UHR)

Intervention Type DIAGNOSTIC_TEST

high UHR is considered to be a risk factor for development of DKI in type 2 DM

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

serum uric acid level to plasma HDL-c level ratio (UHR)

high UHR is considered to be a risk factor for development of DKI in type 2 DM

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Type 2 diabetic patients
* willing and agreed to be included in the study

Exclusion Criteria

* Type 1 DM patients
* patients with active urinary sediment
* patients with glomerulonephritis
* patients with diagnosis or clinical features that are suspicious for another systemic disease that commonly causes kidney disease
* patients with evidence of alternative kidney disease
* patients with history of kidney transplantation
* patients with end stage renal disease
* patients with family history of non diabetic forms of kidney disease
* patients with active malignancy
* patients with established hemolytic disease
* CKD patients requiring dialysis
* patients taking drugs that interfere with serum uric acid level
* patients taking drugs that alter serum lipids level
* pregnancy
* Refused to consent to this study

Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No