Evaluation of Thyroid Function, Lipid Profile, and Uric Acid Levels in Hemodialysis Patients

NCT ID: NCT07157267

Last Updated: 2025-09-05

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2026-07-01
• Study Completion Date: 2027-12-30

Brief Summary

This observational study evaluates the prevalence and relationships of thyroid dysfunction, lipid abnormalities, and elevated uric acid levels in adult patients undergoing maintenance hemodialysis at Assiut University Hospital.

Detailed Description

Chronic kidney disease (CKD) patients on maintenance hemodialysis frequently experience metabolic disturbances including thyroid hormone imbalances, dyslipidemia, and hyperuricemia, which heighten cardiovascular risk. This prospective cross-sectional study aims to investigate the prevalence and interrelations of thyroid function abnormalities (measured via serum TSH, Free T3, Free T4), lipid disorders (total cholesterol, HDL-C, LDL-C, triglycerides), and serum uric acid levels in a cohort of 100 adult patients undergoing regular hemodialysis for at least three months at Assiut University Hospital. Data will be collected through questionnaires, clinical exams, ultrasound thyroid scanning, and detailed laboratory and dialysis records review. The study also examines correlations between these biochemical parameters and patients' demographic and clinical characteristics, such as age, gender, smoking status, dialysis duration/frequency, and comorbidities like diabetes mellitus and hypertension. Statistical analyses using SPSS will identify the prevalence of metabolic alterations and their clinical implications in this vulnerable population.

Conditions

Thyroid Dysfunction; Hemodialysis; Elevated Uric Acid

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

The study population consists of adult patients aged 18 years or older, undergoing regular hemodialy

The study involves 100 adult patients (≥18 years) who are on maintenance hemodialysis for three months or more. Patients with any known thyroid disorder prior to starting dialysis, those receiving lipid-lowering agents or uric acid-lowering medications, and those recently hospitalized or with acute infections in the last month are excluded. The population reflects a typical CKD hemodialysis demographic seen at Assiut University Hospital and includes diverse participants with varying ages, genders, smoking histories, and comorbid conditions such as diabetes mellitus and hypertension. Clinical and demographic data will be systematically gathered, including dialysis durations and adequacy, to provide comprehensive insights into the interplay of thyroid, lipid, and uric acid metabolism in these patients.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Adults ≥18 years
• On regular hemodialysis for ≥3 months

Exclusion Criteria

• On lipid-lowering or uric acid-lowering medications
• Acute infections or hospitalizations in the past month

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Nermen Maher

resident at the Internal Medicine Department

Responsibility Role: PRINCIPAL_INVESTIGATOR

References

Liu WC, Tomino Y, Lu KC. Impacts of uric acid on chronic kidney disease progression: a review. J Adv Res. 2017;8(5):449-56.

Reference Type: BACKGROUND

Other Identifiers

Hemodialysis Patients

Identifier Type: -

Identifier Source: org_study_id