The Efficacity of Hemodiafiltration Versus Hemofiltration for Renal Insufficiency During Intensive Care

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

163 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-04-30

Study Completion Date

2015-03-17

Brief Summary

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The primary objective of this study is to compare the efficacity of hemodiafiltration and hemofiltration for decreasing plasma urea at 12h among intensive care patients. Secondary objectives include comparing urea clearance, filter duration, and %down-time, between the two techniques.

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Detailed Description

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Conditions

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Renal Failure, Acute

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group 1 (hemodiafiltration first)

This group of patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemodiafiltration.

Group Type ACTIVE_COMPARATOR

Hemodiafiltration first

Intervention Type PROCEDURE

Patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemodiafiltration.

Group 2 (hemofiltration first)

This group of patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemofiltration.

Group Type ACTIVE_COMPARATOR

Hemofiltration first

Intervention Type PROCEDURE

Patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemofiltration.

Interventions

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Hemodiafiltration first

Patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemodiafiltration.

Intervention Type PROCEDURE

Hemofiltration first

Patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemofiltration.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* According to RIFLE score, patient is stage 'F'
* The patient must be insured or beneficiary of a health insurance plan
* The patient meets at least one of the following criteria:
* metabolic acidosis (pH \< 7.2), excluding keto-acidosis
* plasma urea \> 25 mmol/l
* hyper-hydration is not controlled by diuretics

Exclusion Criteria

* Chronic, terminal renal insufficiency with dialysis
* The patient is under judicial protection, under tutorship or curatorship
* Suspect hyperkaliemia (Kaliemia \> 6.5 mmol/l with electrocardiographic effects)
* Intoxications treated via dialysis
* Pregnant, lactating, parturient women
* Medical indication for localized citrate anticoagulation
* dialysis of less than 12 h
* patient or representative refuses to participate

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No