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Uremic Toxins in the Intensive Care Unit (ICU): Patients With Sepsis

NCT ID: NCT00752245

Last Updated: 2022-12-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2008-07-31

Study Completion Date

2013-10-04

Brief Summary

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Study of the kinetics of uremic toxins in the ICU patients with acute renal failure, in order to optimize the dialysis dose: patients with sepsis/multi-organ failure. The sampling of blood and dialysate will be done during dialyses with different durations (4, 6 and 8h)

Detailed Description

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Conditions

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Renal Failure Multi Organ Failure

Keywords

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ICU patients with acute renal failure with sepsis/multi-organ failure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Dialysis during 4 hours

Group Type EXPERIMENTAL

Dialysis during 4 hours

Intervention Type PROCEDURE

Blood and dialysate sampling

2

Dialysis during 6 hours

Group Type ACTIVE_COMPARATOR

Dialysis during 6 hours

Intervention Type PROCEDURE

Blood and dialysate sampling

3

Dialysis during 8 hours

Group Type ACTIVE_COMPARATOR

Dialysis during 8 hours

Intervention Type PROCEDURE

Blood and dialysate sampling

Interventions

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Dialysis during 4 hours

Blood and dialysate sampling

Intervention Type PROCEDURE

Dialysis during 6 hours

Blood and dialysate sampling

Intervention Type PROCEDURE

Dialysis during 8 hours

Blood and dialysate sampling

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* ICU patients with sepsis/multi-organ failure with acute renal failure
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Ghent

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Raymond Vanholder, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Ghent

Locations

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University Hospital Ghent

Ghent, , Belgium

Site Status

Countries

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Belgium

Related Links

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http://www.uzgent.be

Website of the University Hospital Ghent

Other Identifiers

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2008/373

Identifier Type: -

Identifier Source: org_study_id