Inflammatory Mediators of Acute Kidney Injury in Intensive Care

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2026-05-31

Brief Summary

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Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality. The mechanisms for sepsis-induced AKI are largely unknown. Our hypothesis is that the inflammatory response to an infection cause collateral damage to host tissue and contributes to the development of AKI. In this study we want to investigate the presence of novel inflammatory mediators in patients with sepsis, patients subjected to major surgery (sterile inflammation) and non-inflamed patients and correlate their levels with the risk for AKI.

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Detailed Description

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Conditions

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Sepsis Surgery Acute Kidney Injury

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Sepsis

Patients admitted to the intensive care unit with sepsis

No interventions assigned to this group

Surgery

Patinets subjected to major surgery and then admitted to the intensive care unit

No interventions assigned to this group

Non-inflamed

Otherwise healthy patients admitted to the intensive care unit because of intoxication.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Patients admitted to the intensive/post operative care unit

* with septic shock or
* post major surgery or
* after intoxication with a chemical compund