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Accuracy of Pre-existing Risk Scoring Models for Predicting Acute Kidney Injury in Patients Who Underwent Aortic Surgery Using a Gray Zone Approach

NCT ID: NCT01844219

Last Updated: 2013-12-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

375 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-04-30

Study Completion Date

2013-09-30

Brief Summary

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Acute kidney injury after cardiac surgery has been reported to increase morbidity and mortality. Several risk scoring models for prediction of aortic kidney injury after cardiac surgery have been developed. However, predictive accuracy of these models is stil unclear. The aim of this study is to evaluate the accuracy of four pre-existing prediction models using a gray zone approach in patients who underwent aortic surgery in our institution.

Detailed Description

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Acute kidney injury after cardiac surgery has been reported to increase morbidity and mortality. Several risk scoring models for prediction of aortic kidney injury after cardiac surgery have been developed. However, predictive accuracy of these models is stil unclear. The aim of this study is to evaluate the accuracy of four pre-existing prediction models (AKICS, Wijeysundera, Mehta, and Thakar model)using a gray zone approach in patients who underwent aortic surgery in our institution. Based on receiver operating characteristic (ROC) curve analysis, we will construct a gray zone using the cut-off values with a sensitivity of \< 90%, and a specificity of \< 90% (diagnostic tolerance of 10%).

Conditions

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Aortic Surgery Postoperative Acute Kidney Injury

Keywords

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aortic surgery acute kidney injury gray zone approach

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patients who underwent aortic surgery

Patients who underwent aortic surgery in Samsung Medical Center during the period between 2004 and 2010

elective or emergency aortic surgery (including ascending, arch, descending thoracic aorta)

Intervention Type PROCEDURE

Interventions

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elective or emergency aortic surgery (including ascending, arch, descending thoracic aorta)

Intervention Type PROCEDURE

Other Intervention Names

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graft interposition of thoracic aorta

Eligibility Criteria

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Inclusion Criteria

* Those who underwent elective or emergency aortic surgery in Samsung Medical Center during between 2004 and 2010.

Exclusion Criteria

* missing laboratory data
* preoperative hemodialysis
* death during or within 48 hours after surgery
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Samsung Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Jong Hwan Lee

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Samsung Medical Center, Sungkyunkwan University, School of Medicine

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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2013-03-059-001

Identifier Type: -

Identifier Source: org_study_id