Prediction of Acute Kidney Injury After Operation of Acute Type A Aortic Dissection Based on Multimodal Model

NCT ID: NCT05017896

Last Updated: 2021-08-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

242 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-09-30

Study Completion Date

2023-02-28

Brief Summary

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Acute kidney injury is one of the most common postoperative complications of acute type A aortic dissection, which is closely related to early postoperative death. Early prevention, early diagnosis and early treatment are the key to improve the prognosis of such patients. It has been a hot topic in clinical research for a long time. Previous reports revealed a series of risk factors for acute kidney injury after aortic dissection, but limited by research design and single modal data, high quality studies were rare. The purpose of this study is to further clarify the risk factors by studying the relationship between preoperative CT renal perfusion imaging indexes and postoperative acute kidney injury; establish and externally verify the multimodal radiomics prediction model for acute kidney injury after operation of aortic dissection combining with preoperative CT renal perfusion imaging and CT angiography information by analysis methods of information fusion, feature engineering and radiomics, so as to guide the follow-up clinical practice, improve the prognosis of such patients and save medical resources.

Detailed Description

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Conditions

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Aneurysm, Dissecting Acute Kidney Injury

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Normal Perfusion

Normal CT Renal Perfusion imaging indexes

Intervention Type DIAGNOSTIC_TEST

A CT imaging which indicates the status of renal perfusion is normal.

Low Perfusion

Low CT Renal Perfusion imaging indexes

Intervention Type DIAGNOSTIC_TEST

A CT imaging which indicates the status of renal perfusion is low.

Interventions

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Normal CT Renal Perfusion imaging indexes

A CT imaging which indicates the status of renal perfusion is normal.

Intervention Type DIAGNOSTIC_TEST

Low CT Renal Perfusion imaging indexes

A CT imaging which indicates the status of renal perfusion is low.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

1. 18-70 years old
2. Acute type A aortic dissection diagnosed by CT angiography
3. Sign informed consent

Exclusion Criteria

1. History of chronic kidney disease
2. History of cardiovascular operation
3. Acute kidney injury has occurred before operation
4. Pregnancy status
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Qilu Hospital of Shandong University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Xin Zhao

Role: PRINCIPAL_INVESTIGATOR

Department of cardiac surgery, Qilu Hospital, Shandong University

Central Contacts

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Xin Zhao

Role: CONTACT

+8618560086772

Other Identifiers

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2020SDUCRCC031

Identifier Type: -

Identifier Source: org_study_id

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