Novel Biomarkers and Postoperative Kidney Injury in Radical Nephrectomy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-08-02

Study Completion Date

2027-07-30

Brief Summary

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The incidence of acute kidney injury (AKI) after radical nephrectomy exceeds 40%. Currently, the KDIGO criteria are the recognized diagnostic standard for AKI. These criteria primarily use serum creatinine and urine output as key indicators, but both parameters have certain limitations, such as delayed response, insensitivity, and inaccuracy. This study aims to simultaneously monitor perioperative novel renal damaging, stressful, and functional biomarkers in patients undergoing radical nephrectomy, and to investigate their predictive value for AKI and postoperative 1-year chronic kidney disease (CKD).

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Detailed Description

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Conditions

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Nephrectomy Acute Kidney Injury Biomarker

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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AKI group/CKD group

1. patients diagnosed with AKI after radical nephrectomy.
2. patients diagnosed with the new onset/worsening of CKD after radical nephrectomy.

No interventions assigned to this group

non-AKI group/non-CKD group

1. patients without AKI after radical nephrectomy.
2. patients without new onset/worsening of CKD after radical nephrectomy.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age ≥18 years;
* Scheduled to undergo unilateral radical nephrectomy.

Exclusion Criteria

* Solitary kidney;
* Preoperative diagnosis of chronic kidney disease stages G4 or G5 (GFR \<30 mL/min/1.73m²);
* Tumor invasion of the vena cava requiring thrombectomy;
* Other conditions deemed by the investigator as unsuitable for participation in this study.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No