Lung Protective Ventilation and Driving Pressure Guided PEEP Titration in CABG Surgery
NCT ID: NCT07044089
Last Updated: 2025-08-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
86 participants
OBSERVATIONAL
2025-07-23
2027-09-01
Brief Summary
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Researcher aimed to compare the effects of two different PEEP application methods on intraoperative hemodynamics, respiratory mechanics, and gas exchange, as well as postoperative extubation times, respiratory complications (atelectasis, need for non invasive mechanical ventilatıon, need for re-entubatıon) length of stay in the intensive care unit, and discharge times.
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Detailed Description
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The secondary goals of the researchers: To compare intraoperative hemodynamics, lung compliance and airway pressures, extubation time and respiratory complications \[development of atelectasis, need for noninvasive mechanical ventilation (high-flow nasal cannula or CPAP application), need for re-intubation\], length of stay in the ICU and discharge times.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Fixed PEEP
No interventions assigned to this group
Indıvıdalızed PEEP
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Patients between the ages of 18 and 70
* ASA (American Society of Anesthesiologists) physical status classification II-III
Exclusion Criteria
* Patients who did not consent to participate in the study
* Patients undergoing emergency surgery
* Patients who are allergic to the anesthetic drugs used
* Patients who have undergone lung resection
* Those with a history of mechanical ventilation in the 2 months before surgery
* Patients who have undergone total circulatory arrest and deep hypothermia
* Patients with obstructive sleep apnea syndrome requiring long-term ventilation assistance
* Morbid obesity (Body Mass Index\>35kg/m2)
* Patients with refractory hypoxemia (arterial oxygen saturation below 88% despite 100% oxygen inhalation)
* COPD (FEV1\<70%)
* Patients with chronic renal failure (serum creatine\>1.8 mg/dl)
* Anemia (Hg\<10 gr/dl)
* Patients who have had an intraaortic balloon pump placed.
18 Years
70 Years
ALL
Yes
Sponsors
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Kocaeli University
OTHER
Responsible Party
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Zeynep AÇIK
Research Assistant Doctor
Locations
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Kocaeli University Faculty of Medicine
Kocaeli, izmit, Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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KAEK/05.b1.01
Identifier Type: -
Identifier Source: org_study_id
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