Effects of Different Peep Applications on Tissue Oxygenation, Respiratory Mechanics and Postoperative Pulmonary Complications in Laparoscopic Hysterectomy Operations
NCT ID: NCT07105293
Last Updated: 2025-08-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
64 participants
INTERVENTIONAL
2023-11-01
2025-02-01
Brief Summary
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Detailed Description
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The study was planned to include 64 patients aged 18-75 years, with ASA status I-III, who provided informed consent and were undergoing elective laparoscopic hysterectomy. The patients were randomized into two groups: one with PEEP 5 cmH₂O and the other with PEEP 10 cmH₂O. The aim was to compare the two groups' hemodynamic variables, NIRS values, peak inspiratory pressure (Ppeak), plateau pressure (Pplato), mean airway pressure (Pmean), end-tidal CO₂ (EtCO₂), driving pressure, serum lactate, partial arterial oxygen (PaO2), and carbon dioxide (PaCO2) levels, recorded after intubation, 30 minutes after pneumoperitoneum, and 15 minutes after desufflation. The ARISCAT score was used to assess the risk of any postoperative pulmonary complications.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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PEEP 5 cmH2o applied group
A standardized anesthesia protocol involved volume-controlled ventilation with a tidal volume of 6-8 mL/kg and a frequency of 10-12 breaths/min. Patients were randomized into two equal groups; one group received PEEP 5 cmH₂O
PEEP 5 cmH2o applied group
A standardized anesthesia protocol involved volume-controlled ventilation with a tidal volume of 6-8 mL/kg and a frequency of 10-12 breaths/min, PEEP:5 cmH2o
PEEP 10 cmH2o applied group
A standardized anesthesia protocol involved volume-controlled ventilation with a tidal volume of 6-8 mL/kg and a frequency of 10-12 breaths/min. Patients were randomized into two equal groups; one group received PEEP 10 cmH₂O
PEEP 10 cmH2o applied group
A standardized anesthesia protocol involved volume-controlled ventilation with a tidal volume of 6-8 mL/kg and a frequency of 10-12 breaths/min, PEEP:10 cmH2o
Interventions
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PEEP 5 cmH2o applied group
A standardized anesthesia protocol involved volume-controlled ventilation with a tidal volume of 6-8 mL/kg and a frequency of 10-12 breaths/min, PEEP:5 cmH2o
PEEP 10 cmH2o applied group
A standardized anesthesia protocol involved volume-controlled ventilation with a tidal volume of 6-8 mL/kg and a frequency of 10-12 breaths/min, PEEP:10 cmH2o
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* ASA IV classification
* Significant pulmonary impairment (moderate/severe chronic obstructive pulmonary disease, emphysema, pulmonary hypertension, etc.)
* Active upper respiratory tract infection or recurrent respiratory infections requiring recent antibiotic treatment
* Severe systemic diseases
* Heavy smoking (≥20 pack-years)
* Emergency surgical cases
* Failure to provide written informed consent for any reason
* Contraindications to PEEP application
18 Years
70 Years
FEMALE
No
Sponsors
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Dr. Lutfi Kirdar Kartal Training and Research Hospital
OTHER_GOV
Responsible Party
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Büşra Şabano
Research Assistant
Locations
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Kartal Dr. Lutfi Kirdar City Hospital
Istanbul, , Turkey (Türkiye)
Countries
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Other Identifiers
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SBU-AVR-BS-01
Identifier Type: -
Identifier Source: org_study_id
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