Effect of Age on PRF Quality; Assessed by Evaluating Healing Outcomes of ARP
NCT ID: NCT07023757
Last Updated: 2025-07-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
NA
44 participants
INTERVENTIONAL
2025-06-12
2026-07-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Platelet-rich fibrin group.
Following extraction, a Platelet-rich fibrin plug will be placed in the extraction socket and covered with a collagen plug.
Socket preservation
After tooth extraction, the extraction socket will be filled with a collagen plug in one group or a platelet-rich fibrin plug in the other.
Collagen plug only
Collagen plug only
Socket preservation
After tooth extraction, the extraction socket will be filled with a collagen plug in one group or a platelet-rich fibrin plug in the other.
Interventions
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Socket preservation
After tooth extraction, the extraction socket will be filled with a collagen plug in one group or a platelet-rich fibrin plug in the other.
Eligibility Criteria
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Inclusion Criteria
2. Patients must require tooth extraction (molars) as a result of caries, periodontal disease, tooth fracture or deemed unrestorable.
3. Non-infected sockets with intact buccal bone (≥1.5 mm in thickness measured through calipers)
4. Patients interested in implant placement following tooth extraction.
Exclusion Criteria
2. Hematologic disorders/blood dyscrasias.
3. Active infectious diseases of any kind.
4. Liver or kidney dysfunction/failure.
5. Uncontrolled diabetes (HbA1c \> 8).
6. Active cancer treatment - such as active chemotherapy or radiation therapy.
7. Taking medications that will affect their bone healing (for example, bisphosphonates, Long-term NSAIDs use, Steroid).
8. Metabolic bone diseases that affect bone healing such as osteoporosis.
9. Pregnant or lactating women (self-reported).
10. Smoke 10 or more cigarettes per day (self-reported).
11. Poor oral hygiene.
12. Systemic diseases that compromise the immune system
13. Anti-coagulant therapy
20 Years
80 Years
ALL
No
Sponsors
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University of Michigan
OTHER
Responsible Party
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Muhammad Saleh
Clinical Assistant Professor, Periodontics and Oral Medicine
Principal Investigators
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Muhammad Saleh, BDS, MSD
Role: PRINCIPAL_INVESTIGATOR
University of Michigan
Locations
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University of Michigan School of Dentistry
Ann Arbor, Michigan, United States
Countries
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Other Identifiers
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HUM00264197
Identifier Type: -
Identifier Source: org_study_id
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