Comparative Evaluation of Two PRF Formulations on Quality of Life and Healing of Apicomarginal Defects
NCT ID: NCT04396743
Last Updated: 2020-05-21
Study Results
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Basic Information
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UNKNOWN
NA
32 participants
INTERVENTIONAL
2019-12-11
2021-04-11
Brief Summary
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Detailed Description
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Recently, autologous platelet concentrates have been used instead of the conventional practice of using GTR barrier membranes for treating apicomarginal defects. Till date no human study has compared platelet formulations; PRF-high ( 2700 rpm for 12minutes) and PRF-medium (1500 rpm for 14minutes) to see any difference in the bony healing and the quality of life between the two groups and no study have assessed bony healing of the periapical defect with periodontal communication with the use of CBCT.
Thus, the aim of the present study is to investigate the effect of 2 different formulations of PRF on quality of life and healing outcome of periapical defects with periodontal communications . Also, in vitro histological and immunohistochemical evaluation and comparison of the clots prepared from different centrifugation protocols will be done .
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Periapical surgery with placement of prf high clots
Patients will undergo periapical surgery and PRF-high clot and membrane will be placed inside the bonycrypt and over the denuded root surface respectively before closure of the flap.
Periapical surgery with use of prf-high clot and membrane
Periapical surgery will be done followed by placement of prf-high clot into the defect and membrane over the defect before closure of the flap.
Periapical surgery with placement of prf medium clots
Patients will undergo periapical surgery and PRF-medium clot and membrane will be placed inside the bonycrypt and over the denuded root surface respectively before closure of the flap.
Periapical surgery with use of prf-medium clot and membrane
Periapical surgery will be done followed by placement of prf-medium clot in the defect and membrane over the defect before closure of the flap.
Interventions
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Periapical surgery with use of prf-high clot and membrane
Periapical surgery will be done followed by placement of prf-high clot into the defect and membrane over the defect before closure of the flap.
Periapical surgery with use of prf-medium clot and membrane
Periapical surgery will be done followed by placement of prf-medium clot in the defect and membrane over the defect before closure of the flap.
Eligibility Criteria
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Inclusion Criteria
2. Patients with no general medical contraindications for oral surgical procedures (ASA-I and ASA-II according to the classification of the American Society of Anesthesiologist's.
3. periapical defect with periodontal communication.
4. Periodontal pocket \>6mm with apicomarginal communication confined to buccal aspect of interproximal space or mid buccal aspect of the root.
5. Negative response to vitality test.
6. failed previous root canal treatment with purulent discharge or failed previous surgery or recurrent episode of purulent discharge.
Exclusion Criteria
2. Unrestorable tooth.
3. fractured /perforated roots.
4. smokers.
5. pregnant females and lactating mothers
16 Years
60 Years
ALL
No
Sponsors
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Postgraduate Institute of Dental Sciences Rohtak
OTHER
Responsible Party
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Locations
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Sanjay Tewari
Rohtak, Haryana, India
Countries
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Facility Contacts
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Other Identifiers
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vidhiendo
Identifier Type: -
Identifier Source: org_study_id
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