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Quadriceps Motor Unit Adaptation to Simulated Knee Injury

NCT ID: NCT06999057

Last Updated: 2025-05-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-01

Study Completion Date

2026-06-01

Brief Summary

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This study investigates how simulated knee injury-via artificial joint effusion or deafferentation-affects quadriceps motor unit behavior in healthy young adults. Participants will complete neuromuscular testing during a single 2-hour lab session. This research seeks to improve understanding of muscle inhibition and inform interventions after real-world knee trauma.

Detailed Description

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Using a controlled laboratory model, the investigators will simulate knee injury through two methods: (1) intra-articular saline injection to induce effusion, and (2) intra-articular lidocaine injection to induce sensory deafferentation. Healthy participants aged 18-30 will undergo surface and decomposition EMG, isometric strength testing, and reflex measurements before and after the intervention. The primary outcome is motor unit recruitment characteristics, with secondary outcomes including quadriceps inhibition (Hoffmann reflex) and isometric peak torque. The findings will inform future neuromodulatory approaches in rehabilitation.

Conditions

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Muscle Inhibition Knee Injury Simulation

Keywords

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Quadriceps Electromyography Motor Unit Knee Effusion Lidocaine Deafferentation Neuromuscular Adaptation Muscle Strength

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Parallel Assignment
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Effusion Group

60 mL sterile saline injected into knee

Group Type EXPERIMENTAL

Joint Effusion via 60 mL Sterile Saline

Intervention Type DEVICE

Injection of sterile saline into the knee joint to simulate joint swelling and induce quadriceps inhibition.

Deafferentation Group

Lidocaine (single intra-articular dose)

Group Type ACTIVE_COMPARATOR

Intra-articular Lidocaine

Intervention Type DRUG

Injection of 7 mL lidocaine into the knee joint to simulate deafferentation by temporarily blocking sensory input.

Control Group

Sham procedure with fake needle

Group Type SHAM_COMPARATOR

Sham injection

Intervention Type OTHER

Simulated knee injection using a stage needle without skin penetration, used to blind participants and serve as control.

Interventions

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Joint Effusion via 60 mL Sterile Saline

Injection of sterile saline into the knee joint to simulate joint swelling and induce quadriceps inhibition.

Intervention Type DEVICE

Intra-articular Lidocaine

Injection of 7 mL lidocaine into the knee joint to simulate deafferentation by temporarily blocking sensory input.

Intervention Type DRUG

Sham injection

Simulated knee injection using a stage needle without skin penetration, used to blind participants and serve as control.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Age 18-30 years
2. Physically active (Tegner ≥ 5)
3. No prior lower-limb surgery or major injury

Exclusion Criteria

1. Lower limb surgery or significant injury in past 2 years
2. Cardiopulmonary, neurological, or psychiatric disorders
3. Needle/electrical stimulation anxiety
4. Medications affecting neuromuscular or psychological function
5. Pregnancy
6. Allergic to lidocaine
7. Inability to elicit Hoffmann reflex
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Central Florida

OTHER

Sponsor Role lead

Responsible Party

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Grant Norte

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Grant Norte, Ph.D.

Role: CONTACT

Phone: 407-823-3188

Email: [email protected]

Meredith Chaput, Ph.D.

Role: CONTACT

Email: [email protected]

Other Identifiers

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Knee_Injection_Study:6295

Identifier Type: -

Identifier Source: org_study_id