Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
40 participants
INTERVENTIONAL
2026-01-31
2027-11-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Additional neuromuscular electrical stimulation (NMES) and blood flow restriction (BFR)
Participants receive a 6-week NMES intervention from week 1 to week 6 post-surgery, followed by a 10-week BFR intervention from week 7 to week 16. Participants also receive standard rehabilitation care as part of their routine postsurgical recovery process.
NMES and BFR
NMES is applied when patients perform quadriceps strengthening exercises. BFR is applied during compound exercises.
Standard physical therapy
Standard physical therapy (week 1-16) includes interventions for typical impairments following ACLR. The initial phase will focus on pain and effusion control, restoration of knee range of motion, followed by gait normalization, lower extremity strength training, then running and plyometrics.
Standard rehabilitation
Participants receive standard rehabilitation care as part of their routine postsurgical recovery process.
Standard physical therapy
Standard physical therapy (week 1-16) includes interventions for typical impairments following ACLR. The initial phase will focus on pain and effusion control, restoration of knee range of motion, followed by gait normalization, lower extremity strength training, then running and plyometrics.
Interventions
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NMES and BFR
NMES is applied when patients perform quadriceps strengthening exercises. BFR is applied during compound exercises.
Standard physical therapy
Standard physical therapy (week 1-16) includes interventions for typical impairments following ACLR. The initial phase will focus on pain and effusion control, restoration of knee range of motion, followed by gait normalization, lower extremity strength training, then running and plyometrics.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* (2) prior knee ligament injury and/or surgery
* (3) multiple ligament injuries and/or ruptures
* (4) conditions in which NMES and BFR are contraindicated
13 Years
17 Years
ALL
No
Sponsors
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Stanford University
OTHER
Responsible Party
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Alexandra Abbott
Clinical Assistant Professor (Orthopedic Surgery)
Principal Investigators
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Alexandra M Abbott, MD
Role: PRINCIPAL_INVESTIGATOR
Stanford School of Medicine
Locations
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Stanford Medicine Children's Health
Sunnyvale, California, United States
Countries
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Facility Contacts
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References
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Ohta H, Kurosawa H, Ikeda H, Iwase Y, Satou N, Nakamura S. Low-load resistance muscular training with moderate restriction of blood flow after anterior cruciate ligament reconstruction. Acta Orthop Scand. 2003 Feb;74(1):62-8. doi: 10.1080/00016470310013680.
Kim KM, Croy T, Hertel J, Saliba S. Effects of neuromuscular electrical stimulation after anterior cruciate ligament reconstruction on quadriceps strength, function, and patient-oriented outcomes: a systematic review. J Orthop Sports Phys Ther. 2010 Jul;40(7):383-91. doi: 10.2519/jospt.2010.3184.
Other Identifiers
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80260
Identifier Type: -
Identifier Source: org_study_id
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