Oxidative Stress and Vitamin D Levels in Autism Spectrum Disorders
NCT ID: NCT06983379
Last Updated: 2025-05-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
68 participants
OBSERVATIONAL
2020-01-03
2023-01-30
Brief Summary
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Detailed Description
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The etiology of Autism Spectrum Disorder (ASD) is thought to be complex. Increasing evidence in the literature shows that oxidative stress plays a role in the development and prognosis of autism. In our study, investigators aimed to investigate whether thiol disulfide balance, which is a new marker of oxidative stress, is different from that in normal children with autism spectrum disorder.
Methods A total of 68 children, 38 with autism spectrum disorder and 30 healthy controls, were included in the study. Dynamic thiol balance, total oxidant status, total antioxidant status, ischemia-modified albumin, paraoxonase 1, and arylesterase activities were measured using colorimetric methods. Routine biochemical parameters were obtained from their files and evaluated.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Autism spectrum disorders
38 individuals with autism spectrum disorders
No interventions assigned to this group
Control
30 healthy individuals
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Children with autism spectrum disorder (Diagnosis based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR))
Exclusion Criteria
* Children who have a family history of chronic medical diseases or psychiatric disorders
* Children who have a family history of chronic medical diseases or psychiatric disorders
0 Years
18 Years
ALL
Yes
Sponsors
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Alanya Alaaddin Keykubat University
OTHER
Mardin Artuklu University
OTHER
Responsible Party
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Hasan Basri Savas
Associate Professor
Locations
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Alanya Training and Research Hospital
Antalya, , Turkey (Türkiye)
Countries
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Other Identifiers
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10354421-2019/5
Identifier Type: -
Identifier Source: org_study_id
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