Ultrasound-guided Pectoral Nerve Blocks, Thoracic Erector Spinae Plane Block and Serratus Anterior Plane Block for Breast Surgery

NCT ID: NCT06947642

Last Updated: 2025-05-20

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-04-30
• Study Completion Date: 2026-09-30

Brief Summary

The study will compare ultrasound-guided Pectoral nerve block, Erector Spinae Plane block, and Serratus anterior plane block for pain management following elective breast surgeries

Detailed Description

Adequate acute postoperative pain control is important for patients undergoing breast surgery because the pain may be severe and longlasting. Surgical incision at the breast and axillary areas is associated with significant pain, with high incidence of acute pain progressing to chronic pain in 25% to 60% of patients. Post-mastectomy pain managed with opioids often lead to side effects of nausea and vomiting.

Regional anesthetic techniques are used in the current management of pain associated with breast surgeries .They attenuate surgical stress response , intraoperative consumption of opioid, prevent central sensitization and diminish postoperative pain.

The efficacy of fascial plane blocks like pectoral nerve block (PECS), serratus anterior plane block (SAP), and erector spinae plane block (ESP) has been proven in previous studies. These blocks require deposition of local anesthetic in an inter-fascial plane through which peripheral nerves travel.

The Pectoral nerve block relies upon the deposition the local anesthetic at the inter-fascial planes among the pectoralis major, minor, and serratus anterior muscles: it blocks the pectoral, the intercostobrachial, the intercostals III and VI, and the long thoracic nerves.

Erector Spinae Plane block is another interfacial plane block. It involves deposition of local anesthetic between erector spinae muscle and transverse process of T5 vertebrae and targets both dorsal and ventral rami of thoracic spinal nerves.

Serratus anterior plane block involves the injection of local anesthetic in 1 of the 2 fascial planes, superficial and deep to serratus anterior muscle at the level of the fifth rib in midaxillary line. The SAP block targets the lateral cutaneous branches of the thoracic intercostal nerves. The deep SAP block was found to have similar analgesic efficacy and technically easier and safer to perform as compared to the superficial SAP block.

Conditions

Ultrasound; Pectoral Nerve Blocks; Thoracic Erector Spinae Plane Block; Serratus Anterior Plane Block; Breast Surgery

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Pectoral nerve block (PECS)

Patients will receive pectoral nerve block (PECS).

Group Type: EXPERIMENTAL

Pectoral nerve block (PECS)

Intervention Type: DRUG

Patients will receive pectoral nerve block (PECS).

Erector spinae plane block (ESP)

Patients will receive erector spinae plane block (ESP).

Group Type: EXPERIMENTAL

Erector spinae plane block (ESP)

Intervention Type: DRUG

Patients will receive erector spinae plane block (ESP).

Serratus anterior plane block (SAP)

Patients will receive serratus anterior plane block (SAP).

Group Type: EXPERIMENTAL

Serratus anterior plane block (SAP)

Intervention Type: DRUG

Patients will receive serratus anterior plane block (SAP).

Interventions

Pectoral nerve block (PECS)

Patients will receive pectoral nerve block (PECS).

Intervention Type: DRUG

Erector spinae plane block (ESP)

Patients will receive erector spinae plane block (ESP).

Intervention Type: DRUG

Serratus anterior plane block (SAP)

Patients will receive serratus anterior plane block (SAP).

Intervention Type: DRUG

Other Intervention Names

Bupivacaine 0.25; Bupivacaine 0.25; Bupivacaine 0.25

Eligibility Criteria

Inclusion Criteria

• Age from 21 to 65 years old female, American Society of Anesthesiologists (ASA) physical status I or II, who will undergo breast surgeries under general anesthesia.

Exclusion Criteria

• Patient refusal to participate in research.
• Body Mass Index (BMI) ≥35 kg/m2.
• Sensitivity to the intervention drugs.
• Coagulation abnormalities.
• Psychiatric disorder and communication difficulties.
• Chronic neurological disease.
• Any skin infection at the needle puncture site.
• Chest wall deformity

• Minimum Eligible Age: 21 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Tanta University

OTHER

Sponsor Role: lead

Responsible Party

Rehab Salah El-Din Taha

Assistant Lecturer of Anesthesiology, Surgical Intensive Care and Pain Management Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Tanta University

Tanta, El-Gharbia, Egypt

Site Status: RECRUITING

Countries

Egypt

Central Contacts

Rehab S Taha, Master

Role: CONTACT

rehabsalah2017@gmail.com

00201000507975

Facility Contacts

Rehab S Taha, Master

Role: primary

rehabsalah2017@gmail.com

00201000507975

Other Identifiers

36265MD276/9/24

Identifier Type: -

Identifier Source: org_study_id