Prevalence of Types and Patterns of Gastrointestinal Polyps in Assiut University Hospitals ( Cross Sectional Study

NCT ID: NCT06929117

Last Updated: 2025-04-16

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 130 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-09-30
• Study Completion Date: 2026-12-31

Brief Summary

Gastrointestinal polyps (GIPs) are unusual growths of epithelial tissue projecting from the mucosa of gastrointestinal tract (GIT) and one of the most common pathologies affecting GIT . They are either proliferative or neoplastic mucosal lesions that are commonly seen in the colon and less commonly occur in the esophagus, stomach and small intestine. They may remain asymptomatic or present as bleeding, pain and obstruction due to mass effect. However, the most important risk with the gastrointestinal polyps is the development of malignancy in some of these polyps . Gastric polyps include hyperplastic, fundic gland polyps, inflammatory fibroid polyp, adenomas like pyloric gland adenoma, and oxyntic gland adenoma. Hyperplastic gastric polyps rarely undergo neoplastic progression (1.5-2.1%) but are associated with an increased risk of synchronous cancer occurring elsewhere in the gastric mucosa . Gastric adenomas are true neoplasms and precursors of gastric cancer. Adenomas larger than 20 mm in width and villous histology have a higher risk of neoplastic progression . The presence of gastric adenomas is strongly associated with synchronous or metachronous gastric adenocarcinoma . Polyps of the small bowel are rare compared to those of the colo-rectum, with adenomas being most common and having more preference for the distal duodenum, ampullary, and periampullary region Colonic Polyps may be classified according to their gross appearance (sessile or pedunculated), histopathological features (hyperplastic, adenoma, etc.), and behavior (benign or malignant). The biggest concern is their ability to progress into adenocarcinoma, through the adenoma to carcinoma sequence due to genetic mutation .

Detailed Description

Gastrointestinal polyps (GIPs) are unusual growths of epithelial tissue projecting from the mucosa of gastrointestinal tract (GIT) and one of the most common pathologies affecting GIT . They are either proliferative or neoplastic mucosal lesions that are commonly seen in the colon and less commonly occur in the esophagus, stomach and small intestine. They may remain asymptomatic or present as bleeding, pain and obstruction due to mass effect. However, the most important risk with the gastrointestinal polyps is the development of malignancy in some of these polyps . Gastric polyps include hyperplastic, fundic gland polyps, inflammatory fibroid polyp, adenomas like pyloric gland adenoma, and oxyntic gland adenoma. Hyperplastic gastric polyps rarely undergo neoplastic progression (1.5-2.1%) but are associated with an increased risk of synchronous cancer occurring elsewhere in the gastric mucosa . Gastric adenomas are true neoplasms and precursors of gastric cancer. Adenomas larger than 20 mm in width and villous histology have a higher risk of neoplastic progression . The presence of gastric adenomas is strongly associated with synchronous or metachronous gastric adenocarcinoma . Polyps of the small bowel are rare compared to those of the colo-rectum, with adenomas being most common and having more preference for the distal duodenum, ampullary, and periampullary region Colonic Polyps may be classified according to their gross appearance (sessile or pedunculated), histopathological features (hyperplastic, adenoma, etc.), and behavior (benign or malignant). The biggest concern is their ability to progress into adenocarcinoma, through the adenoma to carcinoma sequence due to genetic mutation . With the use of Colonoscopy as an outpatient procedure to see inside of the colon and rectum and used in screening, diagnostic and therapeutic of rectal and colon diseases It is vital to discover high-risk polyps during colonoscopy to prevent colorectal cancer. This necessitates a more comprehensive description including morphology, anatomical distribution, and histopathology of those precursor lesions within the entire colon. Among patients with sporadic colorectal polyps, it is important to identify those at risk for malignancy. According to histopathology, serrated polyps, small distal hyperplastic polyps (HPs) have no substantial malignant potential and do not affect colonoscopic surveillance intervals. However, sessile serrated lesions (SSL) and traditional serrated adenomas (TSA) increase the risk of colorectal carcinoma. Generally, high-risk adenoma refers to patients with 1 or more of the following findings: 3 or more adenomas, adenoma ≥10 mm in size, and adenoma with tubulovillous/villous or high-grade dysplasia (HGD) histology . Neoplastic polyps are accountable for roughly 5-10% of population over age of 40 and these are important predisposing factor for majority of large bowel carcinoma cases. The neoplastic polyps are of primary importance because they harbor a malignant potential, which represents a stage in the development of colorectal cancer. For this reason, it is essential to identify these polyps at a sufficiently early stage, when a simple procedure to remove them can stop the development of colorectal cancer and prevent disease and death .

Non neoplastic polyps are important differential diagnosis for the neoplastic polyps and they include: Hyperplastic polyps, Hamartomatous polyps (juvenile polyps) and inflammatory polyps (pseudopolyps). The histopathological study is essential to detect dysplasia.

Conditions

GI Cancer

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

-

Exclusion Criteria

• Patients with insufficient data were excluded

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Alshimaa Ahmed Mohammed Nossier

Resident pathology doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Related Links

http://dx.doi.org/10.1053/s0887-7963(02)80145-6

D.Y. Park et al.Arch Pathol Lab Med(2008)

http://dx.doi.org/10.1601/nm.2236

Nomenclature Abstract for Fulvimonas Mergaert et al. 2002

http://dx.doi.org/10.1016/j.mpdhp.2017.11.001

Colitides: diagnostic challenges and a pattern based approach to differential diagnosis

http://dx.doi.org/10.1007/s00428-018-2400-7

Assarzadegan N, Montgomery E. Gastric polyps. Diagn Histopathol. 2017;23(12):521-9.

Other Identifiers

Prevalence of GIT POlyps

Identifier Type: -

Identifier Source: org_study_id