Inside a Neuron - Ex Vivo Evaluation of Cerebral and Cerebellar Neuronal Activity.

NCT ID: NCT06896331

Last Updated: 2025-03-26

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 60 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-09-17
• Study Completion Date: 2027-09-30

Brief Summary

Understanding the functioning of human neurons has always been a key element, especially with regard to the translation of the inputs they receive into actions that determine human behavior. However, the vast majority of studies have been performed in animal models due to the difficulty in maintaining neuronal functions ex vivo. Recently, techniques have been illustrated that allow us to obtain slices of brain tissue removed during neurosurgical interventions. The patch-clamp and HD-MEA (high density - microelectrodes array) techniques, used until now for animal samples, can allow us to study the functioning of the neural cells that make up these slices. Furthermore, the exploration of the functioning of the aforementioned cells in pathological conditions can open the field for further therapeutic perspectives.

Conditions

Human Neural Cells Functioning

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Study group

Patients subdued to neurosurgical intervention for the removal of brain or cerebellum primary or secondary tumor

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• patients with a brain/cerebellum primary or secondary tumor for whom at least partial resection has been planned.

Exclusion Criteria

• patients with a brain/cerebellum primary or secondary tumor for whom a biopsy has been planned

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Fondazione IRCCS Policlinico San Matteo di Pavia

OTHER

Sponsor Role: lead

Responsible Party

Francesco Guerrini

MD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Fondazione IRCCS Policlinico San Matteo di Pavia

Pavia, Pavia, Italy

Site Status: RECRUITING

Countries

Italy

Central Contacts

Francesco Guerrini, MD

Role: CONTACT

f.guerrini@smatteo.pv.it

+39 0382502780

Facility Contacts

Francesco Guerrini, MD

Role: primary

f.guerrini@smatteo.pv.it

+39 0382502780

Other Identifiers

INSANE

Identifier Type: -

Identifier Source: org_study_id