Core Semantic Systems TMS

NCT ID: NCT06870552

Last Updated: 2025-03-11

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 36 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-04-23
• Study Completion Date: 2025-09-30

Brief Summary

This study examines the time course of activation of the left anterior temporal lobe (ATL) during lexical processing using Transcranial Magnetic Stimulation (TMS).

Detailed Description

This study investigates the activation time of the anterior temporal lobe (ATL) region during lexical processing. Participants will perform three tasks: lexical decision, semantic decision (divided into noun and verb semantic decision), and number judgment.

Lexical Decision Task: Participants will be shown words and pseudowords (e.g., excaid). Participants have to decide if the presented stimulus is a real word or a pseudoword.

Semantic Decision Task: Participants will determine if the stimulus word refers to an action or an object that can be manipulated using the hand or arm.

Half of the stimuli will be nouns, constituting the first semantic decision task with objects, and the other half will be verbs, constituting the second semantic decision task with actions.

Number Judgment Task: Participants will decide if a presented number was divisible by four (e.g., 64) or not (e.g., 69). The stimuli will include numbers with either two or three digits.

For each task, we will collect accuracy and reaction time (RT) data. The primary analyses concern the RTs, but accuracies will also be examined in secondary analyses.

A single pulse TMS will be applied at three different time points: -100 ms, 150 ms, and 400 ms after the onset of the stimulus item. A Magstim BiStim² stimulator with a figure-8 coil will be used. The resting motor threshold (RMT) will be defined as the minimum intensity required to stimulate the motor cortex, eliciting a contraction of the abductor pollicis brevis in at least 5 out of 10 trials. The coil will be positioned at a 45-degree angle along the parasagittal line on the presumed motor cortex area for the APB muscle and adjusted in different directions to find the optimal motor hotspot. Intensity will be between 100% and 120% of resting motor threshold as tolerated by the participant.

The effect of TMS on the response time (RT) at different time points will be examined. TMS will be applied at the left anterior middle temporal gyrus at 10 mm posterior to the tip of the temporal pole. A structural MRI scan will be collected prior to the TMS, which will be used in localizing The target spot. A BrainSight neuronavigation system will be used, with the MRI scan collected before, to localize the target location on the scalp. The tasks will last approximately 30 minutes.

Conditions

Lexical Access in Neurotypicals

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

TMS

Group Type: EXPERIMENTAL

Single-pulse TMS

Intervention Type: DEVICE

A single pulse TMS is delivered at different time points when processing words or numbers.

Interventions

Single-pulse TMS

A single pulse TMS is delivered at different time points when processing words or numbers.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Participants must be within the ages of 18 to 40
• Native speakers of English

Exclusion Criteria

• Potential participants with a clinically reported history of dementia, alcohol abuse, psychiatric or neurological disorders, traumatic brain injury, or extensive vision or hearing problems that prevents them from performing the tasks
• Contraindication to TMS, determined by a standard TMS screening form
• Contraindication to MRI, determined by a standard MRI screening form
• Left handed participants

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Institute on Deafness and Other Communication Disorders (NIDCD)

NIH

Sponsor Role: collaborator

University of South Carolina

OTHER

Sponsor Role: lead

Responsible Party

Rutvik H. Desai

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Prisma Health Richland

Columbia, South Carolina, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Rutvik H Desai, PhD

Role: CONTACT

rutvik@sc.edu

8032617149

Facility Contacts

Rutvik H Desai, PhD

Role: primary

rutvik@sc.edu

803-261-7149

Other Identifiers

R01DC017162

Identifier Type: NIH

Identifier Source: secondary_id

View Link

Pro00098791

Identifier Type: -

Identifier Source: org_study_id