Brain Stimulation Effects on Cognitive Task Performance

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-04-20

Study Completion Date

2027-01-01

Brief Summary

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The purpose of this study is to determine optimal task design parameters for the measurement of transcranial magnetic stimulation (TMS) effects on cognition.

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Detailed Description

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Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that relies on rapidly changing magnetic fields to influence neuronal firing rates. TMS can be used to temporarily inhibit or enhance the firing of populations of neurons located in the cerebral cortex. TMS-induced cortical inhibition versus enhancement is increasingly being used as a tool for exploring brain-behavior relationships and for improving cognitive functioning in people experiencing cognitive deficits due to neuropsychiatric illness (e.g., dementia and schizophrenia). However, important and unresolved methodological issues in this field concern the optimal design of cognitive tasks for TMS stimulation protocols. The purpose of this study is to determine optimal design protocols for online TMS studies of cognitive processes involved in attention, learning, and memory. Research participants will complete cognitive tasks while active versus sham (i.e., non-stimulating) TMS is applied to the brain. A factorial design will be used to determine the combination of task and TMS parameters (i.e., device settings) that produce the most robust and reliable behavioral effects.

Conditions

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Cognitive Function

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Mechanistic study of impact of transcranial magnetic stimulation (TMS) on cognitive function.

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Participants are blinded to TMS therapy, sham control

Study Groups

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Active TMS

Repetitive TMS for the brain

Group Type EXPERIMENTAL

Transcranial Magnetic Stimulation

Intervention Type DEVICE

Transcranial Magnetic Stimulation (TMS) is a noninvasive method for stimulating neurons (axons not cell bodies) in the brain.

Sham TMS

Scalp stimulation that does not affect the brain.

Group Type PLACEBO_COMPARATOR

Transcranial Magnetic Stimulation

Intervention Type DEVICE

Transcranial Magnetic Stimulation (TMS) is a noninvasive method for stimulating neurons (axons not cell bodies) in the brain.

Interventions

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Transcranial Magnetic Stimulation

Transcranial Magnetic Stimulation (TMS) is a noninvasive method for stimulating neurons (axons not cell bodies) in the brain.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Right-handed
* Fluent in English

Exclusion Criteria

* History of seizures or epilepsy
* Family history of epilepsy
* Significant medical or neurological diagnoses
* History of common headache or migraine
* History of common or recent syncope
* History of moderate/severe, multiple mild, or past 12 months head injury
* History of psychiatric, psychological, or neurodevelopmental disorder
* History of alcohol or recreational drug abuse or dependence
* Current visual or hearing difficulties that interfere with cognitive testing
* History of cochlear implants
* Current pregnancy
* History of metal in the head or neck (except braces and fillings)
* Current non-removable piercings in the neck or head
* History of implanted neurostimulator
* History of cardiac pacemaker or intracardiac lines
* History of medication infusion device
* Current use of medications that increase the excitability of the brain
* History of problems with TMS or MRI procedures
* History of EEG for suspected epilepsy
* Alcohol or recreational drug use in the 48 hours prior to TMS
* Inadequate sleep in the 48 hours prior to TMS
* Headache or feeling faint in the 24 hours prior to TMS.

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes