State Dependence of Prefrontal Transcranial Magnetic Stimulation

NCT ID: NCT05962385

Last Updated: 2025-12-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

51 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-08-24

Study Completion Date

2025-11-17

Brief Summary

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The study will examine whether the benefits of brain stimulation on mental functioning can be enhanced if an individual is actively engaging the target brain networks while receiving brain stimulation. The study includes two separate sessions and people will complete either a cognitive task or a perceptual task while receiving transcranial magnetic stimulation. The study will measure change in brain function with EEG.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Repeated measures design - across two separate sessions (one week apart, counterbalanced between participants), participants will receive transcranial magnetic stimulation (TMS) whilst engaging in either a cognitive control or a perceptual task.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

No blinding is possible

Study Groups

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Healthy control

All participants receive the same procedures

Group Type EXPERIMENTAL

Brain state while receiving TMS

Intervention Type DEVICE

Brain state whilst receiving TMS - cognitive control or perceptual. Repeated measures design, so all participants receive the same procedures.

Interventions

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Brain state while receiving TMS

Brain state whilst receiving TMS - cognitive control or perceptual. Repeated measures design, so all participants receive the same procedures.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Age 18 - 65,
* healthy controls

Exclusion Criteria

* Diagnosed psychiatric disorder
* Potential contraindications to EEG (e.g. visible scalp abrasions, non-removable hair extensions and/or hair styling that would impede proper EEG recording)
* Potential contraindication to TMS (as identified by the TMS safety screener)
* Any previous adverse reaction to TMS or MRI
* Diagnosed epilepsy or previously experienced a seizure
* Diagnosed neurological condition, such as stroke or tinnitus
* Experienced a head trauma that was diagnosed as concussion
* Current use of, or recent withdrawal from, medications that can increase the risk of seizure
* Currently pregnant
* Any metal in the head (excluding mouth)
* Any implanted medical device
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Minnesota

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Alik Widge

Role: PRINCIPAL_INVESTIGATOR

University of Minnesota

Locations

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University of Minnesota

Minneapolis, Minnesota, United States

Site Status

Countries

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United States

Other Identifiers

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PSYCH-2023-32060

Identifier Type: -

Identifier Source: org_study_id

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