Brain Network Mechanisms Causally Underlying Human Decisions Revealed by Brain Stimulation and Functional MRI

NCT ID: NCT05027854

Last Updated: 2021-08-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

1800 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-09-01

Study Completion Date

2025-09-30

Brief Summary

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We will examine how stimulation of specific brain areas with transcranial magnetic stimulation (TMS) or transcranial electric stimulation (tES) changes specific aspects of behavior and brain activity, in order to test hypotheses about brain behavior relationships (basic research).

Detailed Description

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Conditions

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Behavior and Behavior Mechanisms

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Stimulation

TMS or tES, depending on experiment

Group Type EXPERIMENTAL

TMS or tES

Intervention Type OTHER

Transcranial magnetic or electric stimulation

Sham

Corresponding sham TMS or tES

Group Type SHAM_COMPARATOR

sham TMS or tES

Intervention Type OTHER

Sham transcranial magnetic or electric stimulation

Interventions

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TMS or tES

Transcranial magnetic or electric stimulation

Intervention Type OTHER

sham TMS or tES

Sham transcranial magnetic or electric stimulation

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* between 18 and 80 years of age (whereby for most studies the majority of recruited participants will be between 18 and 40 years of age)

Exclusion Criteria

* inability to understand the instructions and insufficient knowledge of the project language
* Internal electronic and/or metallic objects in the head, neck, or shoulders (e.g. artificial cochleae, deep brain stimulators, medical pumps, shrapnel, metallic splinters due to accidents during metal welding)
* One or more epileptic fits in the participant or a first-degree relative
* Vascular, traumatic, tumoral, infectious, or metabolic brain damage
* Use of medication that significantly alters cortical excitability
* Acute sleep deprivation or withdrawal from alcohol
* pregnancy
* to reduce bias, students of psychology or economics can be excluded if there is a possibility that they are familiar with the relevant paradigm.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Christian Ruff

OTHER

Sponsor Role lead

Responsible Party

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Christian Ruff

Prof. Dr.

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Christian Ruff, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Zurich

Central Contacts

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Christian Ruff, PhD

Role: CONTACT

+41 44 634 50 67

Other Identifiers

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2020-01490

Identifier Type: -

Identifier Source: org_study_id

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