Acute Effects of Isoenergetic HIIE Vs. MICE on Key Parameters of Fat Mass Loss in Young Females with Overweight or Obesity

NCT ID: NCT06868862

Last Updated: 2025-03-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-02-01

Study Completion Date

2025-12-30

Brief Summary

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Overweight and obesity, particularly increased total and/or abdominal fat mass (FM), are strongly linked to the development of cardiovascular diseases. Managing obesity effectively requires lifestyle and dietary modifications, including increased physical activity. Among the various exercise strategies, Moderate-Intensity Continuous Training (MICT) and High-Intensity Interval Training (HIIT) are widely recommended for reducing FM. Compared to MICT, HIIT is a time-efficient approach, often perceived as more enjoyable, and has been shown to promote greater total and abdominal fat loss in a shorter period. However, the precise mechanisms underlying this enhanced fat loss remain unclear.

This study aims to compare the acute effects of two isoenergetic exercise sessions - MICE (Moderate-Intensity Continuous Exercise) and HIIE (High-Intensity Interval Exercise) - on key physiological responses involved in fat mass loss. Specifically, we will assess plasma catecholamine levels during exercise and recovery, as well as oxygen consumption, substrate oxidation, and appetite over the 2-hour post-exercise period in young females with overweight or obesity. By elucidating the role of catecholaminergic stimulation as a potential regulator of fat mass loss, this research could provide valuable insights for optimizing exercise strategies in weight management and metabolic health.

Detailed Description

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Conditions

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Overweight and Obese Adults High Intensity Interval Exercise (HIIE)

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants
Data collected on the volunteers will be made anonymous.

Study Groups

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High Intensity Interval Exercise

High Intensity Interval Exercise: 5 minutes of WarmUp + 10 x (1 minute at 85% HRmax followed by 1 minute of recovery at a power equivalent to 40% of HRmax)

Group Type EXPERIMENTAL

Exercise

Intervention Type OTHER

Two Exercise Modalities: HIIE and MICE

Moderate Intensity Continuous Exercise

Moderate Intensity Continuous Exercise: 5 minutes of WarmUp + 35 minutes at 55% HRmax

Group Type EXPERIMENTAL

Exercise

Intervention Type OTHER

Two Exercise Modalities: HIIE and MICE

Interventions

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Exercise

Two Exercise Modalities: HIIE and MICE

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* women with overwieght or obesity (BMI: 25-35 kg/m²)

Exclusion Criteria

* contraceptive use
* menopause
* irregular menstrual cycle
* medical contraindications to intense physical activity,
* painful joints,
* taking ß-blocker
Minimum Eligible Age

20 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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LAPEF laboratory, Sao paulo

UNKNOWN

Sponsor Role collaborator

Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Laboratório de Fisiologia e Metabolismo Aplicados à Educação Física

São Paulo, São Paulo, Brazil

Site Status RECRUITING

Countries

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Brazil

Facility Contacts

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JULIANA MONIQUE LINO APARECIDO, PhD

Role: primary

(+55) 1196997-5162

Nathalie Boisseau, Professor

Role: backup

(+33) 0684331693

References

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Dupuit M, Rance M, Morel C, Bouillon P, Pereira B, Bonnet A, Maillard F, Duclos M, Boisseau N. Moderate-Intensity Continuous Training or High-Intensity Interval Training with or without Resistance Training for Altering Body Composition in Postmenopausal Women. Med Sci Sports Exerc. 2020 Mar;52(3):736-745. doi: 10.1249/MSS.0000000000002162.

Reference Type BACKGROUND
PMID: 31524825 (View on PubMed)

Dupuit M, Boscaro A, Bonnet A, Bouillon P, Bruno P, Morel C, Rance M, Boisseau N. Acute metabolic responses after continuous or interval exercise in post-menopausal women with overweight or obesity. Scand J Med Sci Sports. 2020 Dec;30(12):2352-2363. doi: 10.1111/sms.13814. Epub 2020 Sep 18.

Reference Type BACKGROUND
PMID: 32881054 (View on PubMed)

Cunha FA, Midgley AW, McNaughton LR, Farinatti PT. Effect of continuous and intermittent bouts of isocaloric cycling and running exercise on excess postexercise oxygen consumption. J Sci Med Sport. 2016 Feb;19(2):187-92. doi: 10.1016/j.jsams.2015.02.004. Epub 2015 Feb 23.

Reference Type BACKGROUND
PMID: 25747467 (View on PubMed)

Other Identifiers

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CAAE: 79561024.4.0000.9487

Identifier Type: -

Identifier Source: org_study_id

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