Spatial Memory and Temporal Lobe Epilepsy

NCT ID: NCT06847152

Last Updated: 2025-09-22

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 37 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-02-26
• Study Completion Date: 2025-11-12

Brief Summary

Temporal lobe epilepsy (TLE) can cause memory disorders, including long-term forgetfulness due to a failure to consolidate verbal but also spatial information. The forgetting phenomenon presented by these epileptic patients is called accelerated forgetting in the literature and remains difficult to objectify during cognitive assessments. It is indeed particularly complicated to evaluate long-term spatial memory and to account for the topographical complaint, although recurrent, of patients with this TLE.

A navigation task being proposed as part of the neuropsychological assessment of patients with a spatial memory complaint, it is interesting to study the performance pattern of patients with TLE by comparing them to a group of control subjects matched in age and gender in order to verify whether there is significant long-term forgetting and whether there is a significant difference between Right TLE and Left TLE. Indeed, several studies have demonstrated this accelerated long-term forgetting in epileptic patients (Cassel et al., 2016; Lemesle et al., 2017; Landry et al., 2022; Blake et al., 2020) but few with a retention delay of several weeks (Tramoni et al., 2009). This study allows us to statistically analyze the effects of these two groups: epileptic patients and healthy volunteers, but also to combine the effect of the laterality of epilepsy specifically on spatial memory performance.

Detailed Description

In order to assess the long-term spatial memory capacities of epileptic patients with memory complaints, a navigation task was proposed as part of the neuropsychological assessment. This task corresponds to learning a route within the hospital. It is composed of a learning phase and then the patient is asked to repeat the route one hour later and then six weeks later, in order to check for the presence or absence of long-term forgetting. We wanted to study the results of patients with temporal lobe epilepsy (TLE) by comparing them to a group of healthy volunteers matched in age and gender in order to check whether there is significant long-term forgetting and whether there is a significant difference between Right TLE and Left TLE. This study therefore aims to statistically analyze the effects of these two groups: epileptic patients and healthy volunteers, but also to combine the effect of the laterality of epilepsy specifically on spatial memory performance. It will also be interesting to observe whether there is a difference between men and women in the healthy volunteer group for spatial memory learning.

Conditions

Epilepsy Lobe Temporal; Healthy; Epilepsy

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Healthy participant

spatial memory test to healthy participant

Group Type: EXPERIMENTAL

spatial memory test

Intervention Type: DIAGNOSTIC_TEST

The assessment of spatial memory corresponds in our study to a navigation task, i.e. learning a route through the hospital. The route encoding phase is first carried out. The participant follows the experimenter, with the instruction to pay close attention to the route in order to be able to do it again alone. For directions, it is said "this way" or "that way" and not "left" or "right". The route includes 18 intersections.

The participant immediately does the route again alone. The number of correct answers (BR), i.e. correct directions taken at each intersection, is counted as well as the time to complete the route (TR). Direction errors are corrected. This is recall 1.

The participant is then asked to do the route a second time. The correct answers and the times to complete the route are recorded. Errors are corrected (feedback). This is recall 2.

If the participant makes a mistake on recall 1 or 2, a third attempt is made. This is recall 3.

After an interval of 1 hour, the partic

Epileptic patient

spatial memory test to epileptic patient

Group Type: EXPERIMENTAL

spatial memory test

Intervention Type: DIAGNOSTIC_TEST

The assessment of spatial memory corresponds in our study to a navigation task, i.e. learning a route through the hospital. The route encoding phase is first carried out. The participant follows the experimenter, with the instruction to pay close attention to the route in order to be able to do it again alone. For directions, it is said "this way" or "that way" and not "left" or "right". The route includes 18 intersections.

The participant immediately does the route again alone. The number of correct answers (BR), i.e. correct directions taken at each intersection, is counted as well as the time to complete the route (TR). Direction errors are corrected. This is recall 1.

The participant is then asked to do the route a second time. The correct answers and the times to complete the route are recorded. Errors are corrected (feedback). This is recall 2.

If the participant makes a mistake on recall 1 or 2, a third attempt is made. This is recall 3.

After an interval of 1 hour, the partic

Interventions

spatial memory test

The assessment of spatial memory corresponds in our study to a navigation task, i.e. learning a route through the hospital. The route encoding phase is first carried out. The participant follows the experimenter, with the instruction to pay close attention to the route in order to be able to do it again alone. For directions, it is said "this way" or "that way" and not "left" or "right". The route includes 18 intersections.

The participant immediately does the route again alone. The number of correct answers (BR), i.e. correct directions taken at each intersection, is counted as well as the time to complete the route (TR). Direction errors are corrected. This is recall 1.

The participant is then asked to do the route a second time. The correct answers and the times to complete the route are recorded. Errors are corrected (feedback). This is recall 2.

If the participant makes a mistake on recall 1 or 2, a third attempt is made. This is recall 3.

After an interval of 1 hour, the partic

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• healthy volunteers meeting each of the following criteria:

• Aged over 18 years
• Right-handed*
• Free of known neurological pathology
• Signed consent
• Matched in age (+ or - 5 years) and gender with epileptic patients presenting the characteristics below:

• Right-handed*
• adult
• presenting temporal lobe epilepsy, whose lateralization of the epileptogenic focus (right or left) has been objectified by an examination (EEG and/or MRI),
• having carried out a neuropsychological assessment including the navigation task,
• having been informed of the study, and consenting to the processing of their data

Exclusion Criteria

• Person referred to in Article L1121-5 of the Public Health Code: Pregnant, parturient, or breastfeeding women
• Person referred to in Article L1121-6 of the Public Health Code: persons deprived of their judicial or administrative freedom
• Person referred to in Article L1121-8 of the Public Health Code: persons subject to a legal protection measure or unable to express their consent
• Person referred to in Article L1121-8-1 of the Public Health Code: persons not affiliated to a social security scheme
• Left-handed participants
• Participants familiar with the premises of the Centre Hospitalier Métropole Savoie
• Not speaking French

Patients who have undergone epilepsy neurosurgery between the initial visit and the secondary visit of the neuropsychological assessment will not be paired with a healthy volunteer. Their data will not be studied.

Volunteers whose pretest scores reveal a cognitive disorder (pathological threshold > 1.65) will not perform the navigation task. They will then be referred to a neurologist.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Centre Hospitalier Metropole Savoie

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Centre Hospitalier Métropole Savoie

Chambéry, Savoie, France

Site Status: RECRUITING

Countries

France

Central Contacts

Jacqueline BOUCHET

Role: CONTACT

jacqueline.bouchet@ch-metropole-savoie.fr

+33479965161

Fabienne Prieur

Role: CONTACT

fabienne.prieur@ch-metropole-savoie.fr

+33479965999

Facility Contacts

Jacqueline BOUCHET

Role: primary

jaqcueline.bouchet@ch-metropole-savoie.fr

+33479965999

Other Identifiers

CHMS24007

Identifier Type: -

Identifier Source: org_study_id