Functional Connectivity Measurement After Severe Traumatic Brain Injury

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

34 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-03-31

Study Completion Date

2019-10-31

Brief Summary

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To compare functional connectivity after severe traumatic brain injury (TBI) between a group of post-comatose TBI with restored consciousness and a group of post-comatose TBI with persistant disorder of consciousness at admission in rehabilitation

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Detailed Description

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Recovery of consciousness can be impaired in severe traumatic brain injury (TBI). Prognostic factors are sparse and mostly clinical (mainly the initial Glasgow coma scale GCS) (1). Functional magnetic resonance imaging (fMRI) could allow a better understanding of functional recovery. Graph method has been applied to fMRI signal analysis in disorder of consciousness (DOC) due to post-anoxic encephalopathy. Comatose state was characterized by dramatic change in local connectivity (hub location) without significant change in global connectivity (2). The present study aims at describing functional connectivity in DOC following severe TBI. We will record resting state fMRI in TBI patients in two clinical conditions: conscious state versus DOC state.

Conditions

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Disorder of Consciousness

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Conscious patients

group: TBI patients awoken from comatose state with normal level of consciousness.

intervention: fMRI (resting state) and structural (DTI)

MRI: functional (resting state) and structural (DTI)

Intervention Type PROCEDURE

One hour brain MRI recording without active task for the patient, no sedation

DOC patients

group: TBI patients awoken from comatose state with abnormal level of consciousness

intervention: fMRI (resting state) and structural (DTI)

MRI: functional (resting state) and structural (DTI)

Intervention Type PROCEDURE

One hour brain MRI recording without active task for the patient, no sedation

Interventions

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MRI: functional (resting state) and structural (DTI)

One hour brain MRI recording without active task for the patient, no sedation

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* severe TBI
* no general anesthesia since 7 days
* no neuroleptic nor hypnotic drug since 3 days
* medical criteria fulfilled to be discharged from ICU
* medical insurance