Attentional Impairment in People With Epilepsy

NCT ID: NCT04379128

Last Updated: 2020-05-07

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 272 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-05-31
• Study Completion Date: 2025-08-31

Brief Summary

Epilepsy is one of the most common chronic neurological conditions.It leads to cognitive impairment in 20-50% of patients with a structural form.

In comparison with seizures, these cognitive disorders are a major additional factor in occupational, social and family disability. They are particularly frequent (50%) in temporal epilepsies and preferably concern memory and language skills.

The cognitive consequences of epilepsy are therefore well described in the following areas: episodic memory, language, executive functions.

Concerning attentional abilities, a recent review has highlighted the lack of work in this specific field in order to properly measure the prevalence and nature of attentional disorders in epileptic patients. Indeed, attentional abilities are often mentioned in studies, but attention is a complex domain defined by four modalities: alertness, selective attention, divided attention and sustained attention. No study systematically assesses all of these modalities.

The objective of this study is to evaluate the prevalence and nature of attentional disorders in epileptic patients compared to control subjects.

Conditions

Epilepsy

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

patients with epilepsy

Attentional tasks : D2-R task and TAP battery (sustained attention, alertness, divided attention) executive task : digit span, incompatibility and flexibility task (TAP battery), verbal fluencies depression score (NDDI-E scale) and anxiety score (GAD-7 scale)

Attentional tasks

Intervention Type: OTHER

a neuropsychological assessment of attentional task, executive task and interview is proposed to patients or normal control

Normal controls

Attentional tasks : D2-R task and TAP battery (sustained attention, alertness, divided attention) executive task : digit span, incompatibility and flexibility task (TAP battery), verbal fluencies depression score (NDDI-E scale) and anxiety score (GAD-7 scale)

Attentional tasks

Intervention Type: OTHER

a neuropsychological assessment of attentional task, executive task and interview is proposed to patients or normal control

Interventions

Attentional tasks

a neuropsychological assessment of attentional task, executive task and interview is proposed to patients or normal control

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patient with epilepsy, according to Fisher et al. (2005).
• Patient with written informed consent
• affiliation to a social security regime is compulsory
• Individuals who have received full information about the organization of the research and have not objected to their participation and the use of their data.
• Patient 18 years of age and older

Normal controls:

Individuals who have received full information about the organization of the research and have not objected to their participation and the use of their data.

• People 18 years of age and older
• People with no neurological and/or psychiatric history

Exclusion Criteria

for patients: with another progressive neurological condition for all People of full age who are subject to a legal protection measure or who are unable to express their consent People deprived of their liberty by a judicial or administrative decision People who regularly use psychoactive substances (cannabis, alcohol...)

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Central Hospital, Nancy, France

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Central Contacts

helene BRISSART, Dr

Role: CONTACT

h.brissart@chru-nancy.fr

383851689 ext. +33

References

Brissart H, Forthoffer N, Maillard L. Attention disorders in adults with epilepsy. Determinants and therapeutic strategies. Rev Neurol (Paris). 2019 Mar;175(3):135-140. doi: 10.1016/j.neurol.2019.01.394. Epub 2019 Feb 28.

Reference Type: RESULT

PMID: 30826090 (View on PubMed)

Provided Documents

Document Type: Study Protocol

View Document

Other Identifiers

2019-A02748-49

Identifier Type: -

Identifier Source: org_study_id