Structural and Microbiological Characterization of Arterial Catheter Biofilm in ICU's Patients Using Optical Coherence Tomography

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-06-03

Study Completion Date

2025-12-31

Brief Summary

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29.3% of bacteremias in intensive care units (ICU) are linked to vascular devices, including 7.7% to arterial catheters, with an influence on both morbility and mortality.

It is now accepted that biofilm as a role on bacterial development on inner surface of vascular devices but there is yet a lack of clinical relevant data documenting a causal relation between biofilm formation and bacteremias.

The investigators assume that a better structural and microbiological characterization of arterial catheter biofilm in ICU patients could help preventing bacteremias or have a more specific treatment when it appears.

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Detailed Description

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Conditions

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Biofilms Arterial Catheterization, Peripheral Bacteremia Tomography, Optical Coherence

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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OCT-BIO-KTA cohort

Critically ill patient \> 18 years of age with artherial catheter for \>2 calendar days in ICU

OCT-BIO-KTA cohort

Intervention Type OTHER

Dynamic full-field optical coherence tomography (D-FF-OCT) analysis of arterial catheter sections before microbiological analysis of catheter biofilm

Interventions

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OCT-BIO-KTA cohort

Dynamic full-field optical coherence tomography (D-FF-OCT) analysis of arterial catheter sections before microbiological analysis of catheter biofilm

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patient or relative informed of the study and having declared their non-objection
* Patient over 18 years old
* Patient hospitalized in ICU with an arterial catheter

Exclusion Criteria

* Patient unable to express consent
* Patient whose collection of the arterial catheter is impossible or for whom storage at 4°C is impossible
* Patient with arterial catheter removed outside the usual procedure of the ICU
* Patient admitted in ICU with an arterial catheter already in place

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No