Prognosis and Virulence Determination of Capsule and Endotoxin During Klebsiella Spp. Ventilator-associated Pneumonias

NCT ID: NCT05450796

Last Updated: 2022-11-01

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 1000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-06-17
• Study Completion Date: 2024-12-31

Brief Summary

Ventilator-associated pneumonia is the leading cause of nosocomial infection in the ICU. The pathogens responsible are multiple, but enterobacteria constitute a major source of pathogens involved. Within this family, Klebsiella spp. and Escherichia coli are the two most frequent genera, with Klebsiella spp. often present in severe forms. The factors associated with the occurrence of Ventilator-associated pneumonia and its adverse course depend on host defenses and the virulence of the pathogen. The virulence of Klebsiella spp. depends on several structures, notably the presence of a capsule, the particularities of its lipopolysaccharide, its adhesins (type 3 fimbriae), its capacity to capture iron (siderophores). The objective of this work is to evaluate the role of these different virulence mechanisms in the evolution of Ventilator-associated pneumonia and the hospital prognosis.

Conditions

Ventilator-associated Pneumonia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Patient whose age is ≥ 18 years
• Patient hospitalized in an intensive care unit
• Patient with ventilator-associated Klebsiella spp. pneumonia
• French-speaking patient

Exclusion Criteria

• Patient with a severe psychiatric disorder
• Patient under guardianship or curatorship
• Patient deprived of liberty
• Patient under court protection
• Patient who objects to the use of his or her data for this research

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Fondation Hôpital Saint-Joseph

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

François BEAUSSIER, MD

Role: PRINCIPAL_INVESTIGATOR

Fondation Hôpital Saint-Joseph

Locations

Groupe Hospitalier Paris Saint-Joseph

Paris, , France

Site Status: RECRUITING

Countries

France

Central Contacts

François PHILIPPART, MD

Role: CONTACT

fphilippart@ghpsj.fr

144127021 ext. +33

Helene BEAUSSIER, PharmD, PhD

Role: CONTACT

crc@ghpsj.fr

144127883 ext. +33

Facility Contacts

Helene BEAUSSIER, PharmD, PhD

Role: primary

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Other Identifiers

PROVIDENCE

Identifier Type: -

Identifier Source: org_study_id