Bronchial Colonization With Fungi and Late Respiratory Acquired Pneumonia

NCT ID: NCT01770015

Last Updated: 2022-11-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

213 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-11-30

Study Completion Date

2016-09-30

Brief Summary

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Ventilator acquired pneumonia (VAP) are severe nosocomial infections. On the other side, bronchial fungi colonization is commonly observed in ICU; therefore, the investigators propose to study the role of bronchial fungi colonization on the occurrence of VAP taking into account the immune status of the patient and the antibiotic and antifungal treatments he has received.

Detailed Description

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Conditions

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Ventilator Acquired Pneumonia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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ventilated patient

all patients underwent the same diagnostic test . cutaneous, rectal, nose and mouth swabs to identify potential fungi colonization.

HLA DR antigen, cytokines (IL 6 and 10), B-glucan. fungi and bacteria endotracheal aspiration

Group Type EXPERIMENTAL

biological sampling

Intervention Type PROCEDURE

cutaneous, rectal, nose and mouth swabs to identify potential fungi colonization

sampling blood

Intervention Type PROCEDURE

HLA DR antigen, cytokines (IL 6 and 10), B-glucan

endotracheal aspiration

Intervention Type PROCEDURE

fungi and bacteria endotracheal aspiration

Interventions

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biological sampling

cutaneous, rectal, nose and mouth swabs to identify potential fungi colonization

Intervention Type PROCEDURE

sampling blood

HLA DR antigen, cytokines (IL 6 and 10), B-glucan

Intervention Type PROCEDURE

endotracheal aspiration

fungi and bacteria endotracheal aspiration

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patient ventilated for at least 5 days

Exclusion Criteria

* invasive infection Candida sp defined by : candidemia, isolation of Candida from a normally sterile site, candida pneumoniae.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Grenoble

OTHER

Sponsor Role lead

Responsible Party

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AdministrateurDRC

Pr JF TIMSIT

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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TIMSIT Jean-François, PU/PH

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Grenoble

Locations

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Hospital University Clermont Ferrand Gabriel Montpied

Clermont-Ferrand, , France

Site Status

University Hospital of Grenoble

Grenoble, , France

Site Status

Countries

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France

References

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Timsit JF, Schwebel C, Styfalova L, Cornet M, Poirier P, Forrestier C, Ruckly S, Jacob MC, Souweine B. Impact of bronchial colonization with Candida spp. on the risk of bacterial ventilator-associated pneumonia in the ICU: the FUNGIBACT prospective cohort study. Intensive Care Med. 2019 Jun;45(6):834-843. doi: 10.1007/s00134-019-05622-0. Epub 2019 Apr 24.

Reference Type DERIVED
PMID: 31020361 (View on PubMed)

Other Identifiers

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2011-A00767-34

Identifier Type: -

Identifier Source: org_study_id

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