Incidence and Risk Factors for Post-Anesthetic Morphine Titration in Recovery Room After Hip and Knee Arthroplasties

NCT ID: NCT06832995

Last Updated: 2025-02-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-04-01

Study Completion Date

2026-02-28

Brief Summary

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Despite the use of multimodal analgesia combining nerve block (NB) and systemic analgesia, intravenous (IV) morphine titration in the post-anesthetic care unit (PACU) after total hip (THA) and knee (TKA) arthroplasty is required to relieve early moderate-to-severe pain. Sedation occurrence during titration and a VAS score higher than 60/100mm are two independent risk factors for postoperative pain during hospitalization.

The association of NB and multimodal analgesia constitutes the reference in evidence-based recommendations. An adductor or femoral triangle block, alone or associated with periarticular infiltration, is recommended during TKA. During THA, NB associated with surgical periarticular infiltration improves analgesia and rehabilitation This study aims to identify the incidence and risk factors of morphine titration in PACU after lower limb arthroplasty performed by 5 experienced surgeons and using a multimodal analgesic procedure

Detailed Description

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Conditions

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Arthropathy of Hip Arthropathy of Knee

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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group T: IV morphine administered during the PACU stay

IV morphine administered during the PACU stay

Intervention Type DRUG

IV morphine administered during the PACU stay

group NT: no titration required in PACU

No interventions assigned to this group

Interventions

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IV morphine administered during the PACU stay

IV morphine administered during the PACU stay

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Total hip arthroplasty
* Total Knee Arthroplasty
* Uni-compartmental knee arthroplasty (UKA)

Exclusion Criteria

* Bilateral surgery Surgical revision Hip fracture surgery Other osteoarticular procedure(s) associated to hip/knee arthroplasty Refusal to use data Contra-indication of paracetamol, ketoprofen and dexamethasone
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hôpital Privé Sévigné

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hôpital Privé Sévigné

Cesson-Sévigné, , France

Site Status

Countries

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France

Other Identifiers

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2024-HPS

Identifier Type: -

Identifier Source: org_study_id

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