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Ketamine Associated With Morphine PCA After Total Hip Arthroplasty

NCT ID: NCT00797264

Last Updated: 2013-04-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-11-30

Study Completion Date

2010-10-31

Brief Summary

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Ketamine (an analgesic drug often associated with morphine in the treatment of Opioid Induced Hyperalgesia) is often mixed in Morphine PCA syringe. We make the hypothesis that ketamine administrated separately via a continuous infusion, could induced a better analgesic effect.

We will perform a randomised double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion.

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Detailed Description

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Double blind study to determine the best infusion mode of intravenous ketamine, associated with morphine in PCA syringe or alone in continuous infusion

Conditions

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Arthroplasty, Replacement, Hip

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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A

Ketamine pre and per operative, and morphine postoperative

Group Type EXPERIMENTAL

Ketamine-Morphine

Intervention Type DRUG

Ketamine bolus preoperative and syringe pump peroperative, and morphine postoperative (PCA)

B

NaCl pre and per operative, and morphine postoperative

Group Type ACTIVE_COMPARATOR

Morphine

Intervention Type DRUG

Bolus preoperative of NaCl and syringe pump peroperative of NaCl, and morphine postoperative (PCA)

C

Ketamine and morphine postoperative

Group Type EXPERIMENTAL

Postoperative PCA of Ketamine and morphine

Intervention Type DRUG

Bolus preoperative of NaCl and syringe pump peroperative of Ketamine, and morphine postoperative (PCA)

Interventions

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Ketamine-Morphine

Ketamine bolus preoperative and syringe pump peroperative, and morphine postoperative (PCA)

Intervention Type DRUG

Morphine

Bolus preoperative of NaCl and syringe pump peroperative of NaCl, and morphine postoperative (PCA)

Intervention Type DRUG

Postoperative PCA of Ketamine and morphine

Bolus preoperative of NaCl and syringe pump peroperative of Ketamine, and morphine postoperative (PCA)

Intervention Type DRUG

Other Intervention Names

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Ketamine pre and per operative, and morphine postoperative Ketamine Morphine

Eligibility Criteria

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Inclusion Criteria

* total hip arthroplasty

Exclusion Criteria

* pre operative opioid administration
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assistance Publique - Hôpitaux de Paris

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Philippe SITBON, MD

Role: PRINCIPAL_INVESTIGATOR

Assistance Publique - Hôpitaux de Paris Hôpital Bicêtre

Locations

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Service d'anesthesie-reanimation - Hôpital Bicêtre

Le Kremlin-Bicêtre, , France

Site Status

Countries

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France

Other Identifiers

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P060402

Identifier Type: -

Identifier Source: org_study_id

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