Analgesic Efficacy of Intravenous Ketamine as a Continuous Infusion vs PCA in the Management of Acute Postoperative Pain in Major Orthopedic Surgery.

NCT ID: NCT06774274

Last Updated: 2025-04-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE4

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-03-01

Study Completion Date

2027-06-15

Brief Summary

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The goal of this clinical trial is to determine whether treating pain after surgery with ketamine is more effective when administered intravenously as a continuous infusion or through a patient-controlled analgesia (PCA) pump. This study focuses on adult volunteers following major orthopedic surgery. We have two main questions to address:

* Is a continuous intravenous infusion of ketamine as effective as ketamine administered through a PCA pump for managing pain after major orthopedic surgery.
* Does a continuous intravenous infusion of ketamine result in lower opioid requirements compared to ketamine delivered through a PCA pump for pain management after major orthopedic surgery?

Participants will be divided into two groups. One group will receive ketamine via continuous infusion, while the other will receive it through a PCA pump. Both groups will also receive a placebo (a substance that looks like the drug but contains no active ingredients), ensuring that neither group knows whether they are receiving ketamine through the PCA pump (which always contains a painkiller) or as a continuous infusion.

Participants will be assigned to one of the two groups and will receive their assigned treatment for 48 hours while hospitalized. Researchers will visit participants during their first three days in the hospital to assess their pain levels and monitor for any side effects.

Detailed Description

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Managing postoperative pain is a primary concern for patients undergoing major surgery, especially in major orthopedic surgery. Effective pain management is crucial, as uncontrolled postoperative pain can lead to prolonged hospital stays, decreased patient satisfaction, and various complications, including pulmonary and gastrointestinal issues.

Current pain management strategies emphasize multimodal analgesia, which involves using multiple medications with different mechanisms of action to minimize side effects. Ketamine has been investigated in this context and has been found effective for treating postoperative pain following major surgeries while reducing the need for opioids. However, there is still some uncertainty regarding the optimal method for administering ketamine after surgery. The aim of this trial is to compare the effectiveness of intravenous ketamine in terms of pain control, measured by numerical pain scores, and opioid consumption within the first 24 hours postoperatively using two different strategies: continuous infusion versus patient-controlled analgesia (PCA) in adults undergoing non-cardiac surgery.

For this research, two hypotheses are proposed, as the objective involves two types of outcomes related to the analgesic effectiveness of intravenous ketamine: pain measured by a numerical pain scale and opioid consumption equivalent to oral morphine.

Based on data from previous studies, it is highly likely that continuous ketamine infusion will provide similar pain control efficacy at 24 hours compared to PCA ketamine. However, the data suggests that continuous infusion may result in lower opioid consumption than PCA. Therefore, the hypotheses are as follows:

\*\*First Hypothesis\*\* Continuous ketamine infusion is not inferior to PCA ketamine for pain control, as measured by a numerical pain scale at 24 hours postoperatively in patients undergoing major orthopedic surgery with a high risk of severe acute pain.

\*\*Second Hypothesis\*\* Continuous ketamine infusion is superior to PCA ketamine in reducing opioid consumption at 24 hours postoperatively in patients undergoing major orthopedic surgery at high risk of severe acute pain.

This trial will be a triple-blind, parallel-group, pragmatic, non-inferiority controlled clinical trial focused on pain management and superiority regarding opioid use, along with other secondary outcomes.

Conditions

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Pain, Postoperative Opioid Use Major Surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

This trial will be a triple-blind, parallel-group, pragmatic, non-inferiority controlled clinical trial focused on pain management and superiority regarding opioid use, along with other secondary outcomes.
Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors
Treating Anesthesiologist: The anesthesiologist responsible for the case and intraoperative management will be blinded to the assigned intervention. The assignment will be carried out by another anesthesiologist who is not involved in the case. This external anesthesiologist will be present in the operating room, and after opening the envelope, will inform the nursing staff regarding which drug mixtures to prepare.

Data Collection and Analysis Staff: Data will be collected during the hospital stay, up to three days, by two researchers. The researchers will be blinded to the assignment and will not have access to information about the prepared drug mixtures.

Study Groups

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Ketamine infusion

Intravenous ketamine administered as a continuous infusion.

Group Type ACTIVE_COMPARATOR

Ketamine infusion

Intervention Type DRUG

A 10% ketamine solution will be prepared in a 250 cc bag of 0.9% saline (1 mg/cc) using 5 cc from a vial of ketamine that has a concentration of 50 mg/cc. The infusion will be initiated at the time of surgical site closure and will proceed as follows: a bolus of 0.35 cc/kg (equivalent to 0.35 mg/kg) will be administered, followed by a continuous infusion of 0.1 cc/kg/h (equivalent to 0.1 mg/kg/h) for up to 48 hours postoperatively.

Patients in this group will have access to a PCA pump with morphine for analgesic rescue and to monitor daily opioid consumption.

PCA Ketamine

Intravenous ketamine administered along with opioid in a single saline bag using a Patient Controlled Analgesia pump

Group Type ACTIVE_COMPARATOR

PCA Ketamine

Intervention Type DRUG

A mixture of 5% ketamine and 5% morphine will be prepared in a 100 cc bag of 0.9% saline. This will be achieved by using 1 cc of a ketamine vial (50 mg/cc) and 5 cc of a morphine ampule (10 mg/cc). This results in a final concentration of 0.5 mg of ketamine and 0.5 mg of morphine per cc in the 100 cc saline bag.

The pump settings will be configured as follows:

* PCA (Patient-Controlled Analgesia) dose: 2 cc (which delivers 1 mg of ketamine and 1 mg of morphine)
* Lockout interval: 6 minutes
* Maximum dose limit: 15 doses over a 4-hour period

The pump will be available for patient use for up to 48 hours postoperatively.

Interventions

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Ketamine infusion

A 10% ketamine solution will be prepared in a 250 cc bag of 0.9% saline (1 mg/cc) using 5 cc from a vial of ketamine that has a concentration of 50 mg/cc. The infusion will be initiated at the time of surgical site closure and will proceed as follows: a bolus of 0.35 cc/kg (equivalent to 0.35 mg/kg) will be administered, followed by a continuous infusion of 0.1 cc/kg/h (equivalent to 0.1 mg/kg/h) for up to 48 hours postoperatively.

Patients in this group will have access to a PCA pump with morphine for analgesic rescue and to monitor daily opioid consumption.

Intervention Type DRUG

PCA Ketamine

A mixture of 5% ketamine and 5% morphine will be prepared in a 100 cc bag of 0.9% saline. This will be achieved by using 1 cc of a ketamine vial (50 mg/cc) and 5 cc of a morphine ampule (10 mg/cc). This results in a final concentration of 0.5 mg of ketamine and 0.5 mg of morphine per cc in the 100 cc saline bag.

The pump settings will be configured as follows:

* PCA (Patient-Controlled Analgesia) dose: 2 cc (which delivers 1 mg of ketamine and 1 mg of morphine)
* Lockout interval: 6 minutes
* Maximum dose limit: 15 doses over a 4-hour period

The pump will be available for patient use for up to 48 hours postoperatively.

Intervention Type DRUG

Other Intervention Names

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Ketamine PCA

Eligibility Criteria

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Inclusion Criteria

* Patients over 18 years of age
* Elective major orthopedic surgery.
* ASA (American Association of Anesthesiology) classification 1, 2 or 3.

Exclusion Criteria

* Patients with a diagnosis of perioperative kidney injury or hepatic failure
* Patients with active cardiac conditions
* Patients with any cognitive impairment that disables the patient from operating the PCA pump or impedes the postoperative interview
* Patients with scheduled ICU admission with invasive ventilatory support
* Patients with known hypersensitivity to opioid medications
* Patients with past medical history of severe adverse reactions to opioids or ketamine.
* Pregnant patients
* Patients undergoing continuous regional anesthetic techniques including peripheral nerve catheters or continuous epidural catheters
* Patient refusal to participate in the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hospital San Vicente Fundación

OTHER

Sponsor Role collaborator

Universidad de Antioquia

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Fabian D Casas, Professor

Role: STUDY_CHAIR

Universidad de Antioquia

Locations

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St. Vincent's Foundation University Hospital

Medellín, Antioquia, Colombia

Site Status RECRUITING

Countries

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Colombia

Central Contacts

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Fabian D Casas, Professor

Role: CONTACT

+57 (604) 300574882

Mateo Aristizabal, Resident

Role: CONTACT

+57 3104285832

References

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Other Identifiers

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36-2024

Identifier Type: -

Identifier Source: org_study_id

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