Evaluation of Ketamine and Multi-modal Analgesics

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2016-07-31

Study Completion Date

2018-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this research study is to see if pain can be better controlled with fewer side effects. The new drug regimen will study several different medicines that have different ways of treating pain.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Multimodal Analgesia for the Reduction of Postoperative Opioid Consumption

NCT03817034

Pain

WITHDRAWN EARLY_PHASE1

Postoperative Pain Protocol Limiting Narcotics for Laparoscopic Hand-assisted Donor Nephrectomy

NCT06458842

Narcotic Use Renal Transplant Donor of Left Kidney

TERMINATED NA

Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia

NCT01301079

Pain Hyperalgesia Inflammatory Response

COMPLETED PHASE3

Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty

NCT07059429

Knee Arthroplasty Postoperative Pain Pain Management +3 more

RECRUITING NA

The Effect of Perioperative Ketamine on Acute and Chronic Pain After Major Back Surgery

NCT00618423

Postoperative Pain

COMPLETED PHASE2

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The investigators plan to study an analgesic regimen of Ketamine and Lidocaine as infusions with Neurontin and acetaminophen delivered orally for postoperative analgesia and the subsequent effect on ventilator days and ICU stay. The investigators expect that pain scores will be either unchanged or better than historic controls. In addition, the investigators expect that ventilator days and ICU stay will be improved due to reduced incidence of delirium and bowel dysfunction.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pain

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Control Group

Intensivists will proceed with analgesia utilizing conventional opioid based pain order sets.

No interventions assigned to this group

Study Group

The investigators plan to study an analgesic regimen of Ketamine and lidocaine as infusions with Neurontin and Acetaminophen delivered orally for postoperative analgesia and the subsequent effect on ventilator days and ICU stay.

Ketamine

Intervention Type DRUG

Receive an analgesic regimen that involves Ketamine infusions

Lidocaine

Intervention Type DRUG

Receive an analgesic regimen that involves Lidocaine infusions

Acetaminophen

Intervention Type DRUG

May be administered Acetaminophen rectally, by mouth, or intravenously in patients not suitable for either of the other methods of administration

Neurontin

Intervention Type DRUG

May be given Neurontin by mouth as an approved medication for pain control

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Ketamine

Receive an analgesic regimen that involves Ketamine infusions

Intervention Type DRUG

Lidocaine

Receive an analgesic regimen that involves Lidocaine infusions

Intervention Type DRUG

Acetaminophen

May be administered Acetaminophen rectally, by mouth, or intravenously in patients not suitable for either of the other methods of administration

Intervention Type DRUG

Neurontin

May be given Neurontin by mouth as an approved medication for pain control

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Ketalar Lidopen Tylenol Gabapentin

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* American Society of Anesthesiologists (ASA) status 1-4
* Undergoing planned surgery for cardiac problems
* 18 years of age and not older than 85 years of age

Exclusion Criteria

* Severe liver disease (alanine aminotransferase (ALT) , aspartate aminotransferase (AST), or bilirubin \> 2.5 times Upper Limit of Normal)
* Pregnancy or currently breastfeeding
* History of schizophrenia or other hallucinatory psychiatric disorder
* History of chronic or pre-existing pain disorder
* History of heart block
* Severe renal impairment Creatinine Clearance (CrCl)\<30 milliliter(mL)/min

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No