Efficacy of Ketamine in Post Anesthesia Recovery Room

NCT ID: NCT04701008

Last Updated: 2024-09-19

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 143 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-09-01
• Study Completion Date: 2021-05-28

Brief Summary

Observational study to assess efficacy of IV ketamine bolus when used in the post anesthesia recovery unit for uncontrolled pain despite use of opioids.

Detailed Description

In this observational study, the investigators will monitor all patients with significant pain after any non-cardiac surgical intervention at the University of Alberta Hospital.

After receiving an adequate dose of potent opioids (hydromorphone, morphine), the participants will receive up to 0,2-0,25 mg/kg IV ketamine bolus. In our center these boluses are given with 10-20mg increments.

The adequate dose of opioids will be determined by the attending anesthesiologist, depending on what patients received intraoperatively and on their comorbidities.

Pain scores will be assessed before and after administration of this drug. The incidence of any side effect after ketamine administration will be documented.

Conditions

Pain, Postoperative; Ketamine Adverse Reaction; Pain, Refractory; Pain, Intractable; Pain, Acute

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Patients with significative post-operative pain despite

Patients with significant pain despite receiving narcotics in PACU will receive a bolus dose of IV ketamine to assess its efficacy for pain score reduction. Bolus doses are given by 10mg IV increments, to reach approximate dose of 0,25mg/kg.

Ketamine

Intervention Type: DRUG

IV ketamine - 10mg bolus may be repeated repeated 2-3 times depending on clinical judgement

Interventions

Ketamine

IV ketamine - 10mg bolus may be repeated repeated 2-3 times depending on clinical judgement

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

Adult patients undergoing non cardiac surgery at University of Alberta Hospital meeting the following criteria:

• age ≥ 18
• significant pain despite narcotics used in post-anesthesia care unit
• ketamine ordered by attending anesthesiologist

Exclusion Criteria

• Patient refusal to receive ketamine
• Patients undergoing cardiac surgery
• Patients who received no narcotics
• Contra-indication to receiving ketamine (determined by attending anesthesiologist)

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Alberta

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

University of Alberta Hospital

Edmonton, Alberta, Canada

Countries

Canada

References

Brinck EC, Tiippana E, Heesen M, Bell RF, Straube S, Moore RA, Kontinen V. Perioperative intravenous ketamine for acute postoperative pain in adults. Cochrane Database Syst Rev. 2018 Dec 20;12(12):CD012033. doi: 10.1002/14651858.CD012033.pub4.

Reference Type: BACKGROUND

PMID: 30570761 (View on PubMed)

Gillies A, Lindholm D, Angliss M, Orr A. The use of ketamine as rescue analgesia in the recovery room following morphine administration--a double-blind randomised controlled trial in postoperative patients. Anaesth Intensive Care. 2007 Apr;35(2):199-203.

Reference Type: BACKGROUND

PMID: 17444308 (View on PubMed)

Weinbroum AA. A single small dose of postoperative ketamine provides rapid and sustained improvement in morphine analgesia in the presence of morphine-resistant pain. Anesth Analg. 2003 Mar;96(3):789-795. doi: 10.1213/01.ANE.0000048088.17761.B4.

Reference Type: BACKGROUND

PMID: 12598264 (View on PubMed)

Other Identifiers

Pro00102967

Identifier Type: -

Identifier Source: org_study_id