Oral and Intravenous Methadone for Analgesia in Cardiac Surgery
NCT ID: NCT06720415
Last Updated: 2026-01-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
41 participants
INTERVENTIONAL
2025-04-14
2025-07-14
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Oral methadone, immediately prior to transport
Oral methadone, immediately prior to transport
Patients will receive 0.4mg/kg PO methadone immediately prior to transport to the operating room
Intravenous methadone
Intravenous methadone
Patients will receive 0.3mg/kg IV methadone after induction of general anesthesia
Interventions
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Oral methadone, immediately prior to transport
Patients will receive 0.4mg/kg PO methadone immediately prior to transport to the operating room
Intravenous methadone
Patients will receive 0.3mg/kg IV methadone after induction of general anesthesia
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Opioid use disorder on medication assistance treatment
* Prolonged QTc \> 500ms
* Chronic kidney disease with eGFR \< 30mL/min
* Documented cirrhosis
* Intolerance to methadone
* Subsequent surgeries after index surgery
18 Years
ALL
No
Sponsors
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Mayo Clinic
OTHER
Responsible Party
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Krishnan Ramanujan
Principal Investigator
Principal Investigators
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Krishnan Ramanujan
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic
Locations
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Mayo Clinic in Rochester
Rochester, Minnesota, United States
Countries
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Other Identifiers
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24-006579
Identifier Type: -
Identifier Source: org_study_id
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