MedDataX Logo

Intrathecal Morphine in Knee Arthroplasty

NCT ID: NCT00695045

Last Updated: 2008-06-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-07-31

Study Completion Date

2007-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement.We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pain, Postoperative Arthroplasty, Replacement, Knee

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Pain, Postoperative Arthroplasty, Replacement, Knee Morphine Injections, Intrathecal

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

patients in this group got 100mcg of intrathecal morphine.

Group Type EXPERIMENTAL

intra thecal morphine

Intervention Type DRUG

100 mcg intrathecal morphine given once .

2

patients in this group got 200 mcg intrathecal morphine

Group Type EXPERIMENTAL

intra thecal morphine

Intervention Type DRUG

200 mcg intrathecal morphine given once

3

patients in this group given 300 mcg intrathecal morphine.

Group Type EXPERIMENTAL

intra thecal morphine

Intervention Type DRUG

300 mcg intrathecal morphine given once

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

intra thecal morphine

100 mcg intrathecal morphine given once .

Intervention Type DRUG

intra thecal morphine

200 mcg intrathecal morphine given once

Intervention Type DRUG

intra thecal morphine

300 mcg intrathecal morphine given once

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

intraspinal morphine intra spinal morphine intra spinal morphine

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients for elective total knee arthroplasty

Exclusion Criteria

* No contraindication to spinal
* No allergy to morphine, rescue analgesia or anti-emesis treatment.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University College Hospital Galway

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Department of Anaesthesia , University College Hospital Galway

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Patrick D Hassett, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Anaesthesia, UCHG

John Laffey, MD

Role: STUDY_CHAIR

Department of Anaesthesia,UCHG

Brian Kinirons, MD

Role: STUDY_DIRECTOR

Dept of Anaesthesia , UCHG

References

Explore related publications, articles, or registry entries linked to this study.

Hassett P, Ansari B, Gnanamoorthy P, Kinirons B, Laffey JG. Determination Of The Efficacy And Side-effect Profile Of Lower Doses Of Intrathecal Morphine In Patients Undergoing Total Knee Arthroplasty. BMC Anesthesiol. 2008 Sep 24;8:5. doi: 10.1186/1471-2253-8-5.

Reference Type DERIVED
PMID: 18816386 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

0001

Identifier Type: -

Identifier Source: org_study_id