Study Results
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Basic Information
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RECRUITING
NA
66 participants
INTERVENTIONAL
2024-12-01
2026-03-31
Brief Summary
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Detailed Description
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Parietal and prefrontal areas are also involved in the processing of self-related information. In particular, the right lateral parietal cortex is more involved in retrieving self-related information than other-related information. Regarding the role of prefrontal regions in processing the self, the vmPFC shows greater activity when imagining a mental scenario related to the self rather than to another person.
To better understand MTT ability, two important questions arise from the review of the relevant literature. First, does self-related information affect our ability to mentally travel in time? If so, may these two processes interact in the same brain areas? VmPFC might be a good candidate for the interaction between future projection and self-processing: self-related stimuli could increase one's ability to "move" to future MTT.
Regarding past and self-related processing, the role of the right lateral parietal cortex is still unclear. IPL neural activity could underlie both processes, thus revealing a crucial centre for the interplay between MTT past projection and self-processing (autobiographical component of MTT).
The purpose of the present study is to investigate the influence of self-related stimuli in MTT tasks in patients with focal brain injury. Specifically, the authors will test for the first time whether the temporal distance between present time and the likelihood that a life event will occur (or has already occurred) is different whether the event is referred to one's own face or someone else's face.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Healthy participants
All participants performed the MTT task, the Age estimation task and the Lifeline task.
Mental Time Travel task
A psychophysical task (D'Angelo et al., 2023) will be adopted. In this task, a projection in time will be "induced" by faces of different ages. Face stimuli will be presented with a short sentence describing a particular life event, commonly occurring around 60. Participants will perform a two-alternative forced-choice task under two experimental conditions. In the "past projection" condition, they will indicate whether it is "likely" or "unlikely" that the person of the face shown could have experienced the indicated event 10 years earlier. In the "future projection," they will indicate whether it is "likely" or "unlikely" that the person depicted will experience the indicated event in 10 years.
Age Estimation control task
In this task participants will estimate the age of the faces adopted as stimuli.
Lifeline task
In this task participants will be instructed to associated each event with the age at which they believe it typically occurred.
vmPFC patients
All participants performed the MTT task, the Age estimation task and the Lifeline task.
Mental Time Travel task
A psychophysical task (D'Angelo et al., 2023) will be adopted. In this task, a projection in time will be "induced" by faces of different ages. Face stimuli will be presented with a short sentence describing a particular life event, commonly occurring around 60. Participants will perform a two-alternative forced-choice task under two experimental conditions. In the "past projection" condition, they will indicate whether it is "likely" or "unlikely" that the person of the face shown could have experienced the indicated event 10 years earlier. In the "future projection," they will indicate whether it is "likely" or "unlikely" that the person depicted will experience the indicated event in 10 years.
Age Estimation control task
In this task participants will estimate the age of the faces adopted as stimuli.
Lifeline task
In this task participants will be instructed to associated each event with the age at which they believe it typically occurred.
not-vmPFC patients
All participants performed the MTT task, the Age estimation task and the Lifeline task.
Mental Time Travel task
A psychophysical task (D'Angelo et al., 2023) will be adopted. In this task, a projection in time will be "induced" by faces of different ages. Face stimuli will be presented with a short sentence describing a particular life event, commonly occurring around 60. Participants will perform a two-alternative forced-choice task under two experimental conditions. In the "past projection" condition, they will indicate whether it is "likely" or "unlikely" that the person of the face shown could have experienced the indicated event 10 years earlier. In the "future projection," they will indicate whether it is "likely" or "unlikely" that the person depicted will experience the indicated event in 10 years.
Age Estimation control task
In this task participants will estimate the age of the faces adopted as stimuli.
Lifeline task
In this task participants will be instructed to associated each event with the age at which they believe it typically occurred.
Interventions
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Mental Time Travel task
A psychophysical task (D'Angelo et al., 2023) will be adopted. In this task, a projection in time will be "induced" by faces of different ages. Face stimuli will be presented with a short sentence describing a particular life event, commonly occurring around 60. Participants will perform a two-alternative forced-choice task under two experimental conditions. In the "past projection" condition, they will indicate whether it is "likely" or "unlikely" that the person of the face shown could have experienced the indicated event 10 years earlier. In the "future projection," they will indicate whether it is "likely" or "unlikely" that the person depicted will experience the indicated event in 10 years.
Age Estimation control task
In this task participants will estimate the age of the faces adopted as stimuli.
Lifeline task
In this task participants will be instructed to associated each event with the age at which they believe it typically occurred.
Eligibility Criteria
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Inclusion Criteria
* the presence of a focal brain lesion will be adopted as an inclusion criterion for patients.
Exclusion Criteria
* multiple brain lesions
40 Years
80 Years
ALL
Yes
Sponsors
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Centro Studi e Ricerche in Neuroscienze Cognitive (Cesena)
UNKNOWN
Istituti Clinici Scientifici Maugeri SpA
OTHER
Responsible Party
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Principal Investigators
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Giuliana Vezzadini, MD
Role: PRINCIPAL_INVESTIGATOR
Istituti Clinici Scientifici Maugeri
Locations
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Istituti Clinici Scientifici Maugeri
Castel Goffredo, Mantova, Italy
Countries
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Central Contacts
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Facility Contacts
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References
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Hutchinson JB, Uncapher MR, Wagner AD. Posterior parietal cortex and episodic retrieval: convergent and divergent effects of attention and memory. Learn Mem. 2009 May 23;16(6):343-56. doi: 10.1101/lm.919109. Print 2009 Jun.
Bonato M, Saj A, Vuilleumier P. Hemispatial Neglect Shows That "Before" Is "Left". Neural Plast. 2016;2016:2716036. doi: 10.1155/2016/2716036. Epub 2016 May 29.
Lou HC, Luber B, Crupain M, Keenan JP, Nowak M, Kjaer TW, Sackeim HA, Lisanby SH. Parietal cortex and representation of the mental Self. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6827-32. doi: 10.1073/pnas.0400049101. Epub 2004 Apr 19.
De Brigard F, Nathan Spreng R, Mitchell JP, Schacter DL. Neural activity associated with self, other, and object-based counterfactual thinking. Neuroimage. 2015 Apr 1;109:12-26. doi: 10.1016/j.neuroimage.2014.12.075. Epub 2015 Jan 8.
D'Argembeau A, Jedidi H, Balteau E, Bahri M, Phillips C, Salmon E. Valuing one's self: medial prefrontal involvement in epistemic and emotive investments in self-views. Cereb Cortex. 2012 Mar;22(3):659-67. doi: 10.1093/cercor/bhr144. Epub 2011 Jun 16.
Schacter DL, Addis DR, Hassabis D, Martin VC, Spreng RN, Szpunar KK. The future of memory: remembering, imagining, and the brain. Neuron. 2012 Nov 21;76(4):677-94. doi: 10.1016/j.neuron.2012.11.001.
Kaller CP, Rahm B, Spreer J, Weiller C, Unterrainer JM. Dissociable contributions of left and right dorsolateral prefrontal cortex in planning. Cereb Cortex. 2011 Feb;21(2):307-17. doi: 10.1093/cercor/bhq096. Epub 2010 Jun 3.
Ciaramelli E, Anelli F, Frassinetti F. An asymmetry in past and future mental time travel following vmPFC damage. Soc Cogn Affect Neurosci. 2021 Mar 5;16(3):315-325. doi: 10.1093/scan/nsaa163.
D'Argembeau A, Van der Linden M. Phenomenal characteristics associated with projecting oneself back into the past and forward into the future: influence of valence and temporal distance. Conscious Cogn. 2004 Dec;13(4):844-58. doi: 10.1016/j.concog.2004.07.007.
D'Angelo M, Frassinetti F, Cappelletti M. The Role of Beta Oscillations in Mental Time Travel. Psychol Sci. 2023 Apr;34(4):490-500. doi: 10.1177/09567976221147259. Epub 2023 Feb 16.
Other Identifiers
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ICS Maugeri CE 2717
Identifier Type: -
Identifier Source: org_study_id
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