Effect of Glycerol Hyperhydration on Running Economy of Long-distance Runners
NCT ID: NCT06818253
Last Updated: 2025-02-10
Study Results
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Basic Information
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COMPLETED
NA
30 participants
INTERVENTIONAL
2022-11-10
2024-01-13
Brief Summary
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1. Does hyperhydration with glycerol improve running economy?
2. Are there beneficial effects on physical performance?
The researchers will conduct a clinical trial with 30 runners (15 men, 15 women) in three sessions. In the first session, VO2peak was determined and running speeds were established for sessions 2 and 3. In the second session, participants performed a stress test. In the second session, participants performed a running test in the euhydrated state under fluid restriction, and in the third session, with glycerol supplementation (22 ml/kg sports drink + 1.2 g/kg glycerol). Variables such as caloric cost unit (CCU), oxygen cost unit (OCU), heart rate (HR), body temperature (BT) and perceived exertion (RPE) were evaluated.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Arm glycerol supplementation
This arm participated in a crossover design allowed minimizing interindividual variability by using each participant as their own control, evaluating the conditions of (1) hyperhydration with glycerol and (2) water restriction. The main variables evaluated were maximal oxygen consumption (VO₂max), running economy (CE), calculated using the oxygen cost unit (OCU) and caloric cost unit (CCU), as well as body temperature, perception of exertion and sweating rate.
The Effect of Glycerol Supplements
The main factor that distinguishes this intervention is first of all the dosage of the dietary supplement and the effects on the variables to be analyzed related to physical performance.
Interventions
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The Effect of Glycerol Supplements
The main factor that distinguishes this intervention is first of all the dosage of the dietary supplement and the effects on the variables to be analyzed related to physical performance.
Eligibility Criteria
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Inclusion Criteria
2. Age between 18 and 35 years old
3. Apparently healthy athletes
4. Signature of informed consent form
Exclusion Criteria
2. Consumption of medications or stimulants (such as caffeine or diuretics) 48 hours before the tests.
3. Pregnancy.
\-
18 Years
35 Years
ALL
Yes
Sponsors
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University of Guadalajara
OTHER
Iberoamerican Institute of Sports Science and Human Movement
OTHER
Responsible Party
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Cesar Octavio Ramos Garcia, PhD
Chief Research Officer (CRO)
Locations
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Universidad de Guadalajara, Centro Universitario de Tonalá
Guadalajara, Jalisco, Mexico
Countries
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References
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Jolicoeur Desroches A, Naulleau C, Deshayes TA, Parent-Roberge H, Pancrate T, Goulet EDB. Effect of Glycerol-Induced Hyperhydration on a 5-kilometer Running Time-Trial Performance in the Heat in Recreationally Active Individuals. Nutrients. 2023 Jan 24;15(3):599. doi: 10.3390/nu15030599.
Herrera-Amante CA, Garcia-Zepeda G, Garcia-Zepeda CE, Yanez-Sepulveda R, Clemente-Suarez VJ, Lopez-Gil JF, Octavio Ramos-Garcia C. Effects of glycerol hyperhidration on the running economy of long-distance runners: a randomized crossover clinical trial. Front Nutr. 2025 Aug 13;12:1630462. doi: 10.3389/fnut.2025.1630462. eCollection 2025.
Other Identifiers
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IICDEM-ID-001-2022
Identifier Type: -
Identifier Source: org_study_id
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