Screening of Small Non-coding RNAs as an Auxiliary Diagnostic Biomarker for Gastric Cancer
NCT ID: NCT06776835
Last Updated: 2025-01-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
300 participants
OBSERVATIONAL
2023-12-10
2026-11-30
Brief Summary
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Detailed Description
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Small non-coding RNA species include microRNA (miRNA), PIWI-interacting RNA (piRNA), small interfering RNA (siRNA), tRNA-derived small RNA (tsRNA), etc. It has been demonstrated by previous scientific researches that small non-coding RNAs are involved in gastric cancer cell proliferation, metastasis, progression and survival. Hence, it is considered as a new biomarker panel for gastric cancer.
The purpose of the present clinical trail is to explore the correlation between small non-coding RNAs panel and early gastric cancer, and to elucidate the possibility of small non-coding RNAs panel as a biomarker for gastric cancer. Verify the experimental purpose by monitoring the relative quantification of small non-coding RNAs panel through high-throughput sequencing and qRT PCR technology.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Gastric cancer cases from medical centers in China
Measurement of levels of circulating small non-coding RNAs
Analysis of relative quantitative of small non-coding RNAs
Each participant was enrolled to assess the of relative quantitative of small non-coding RNAs
Controls from medical centers in China
Measurement of levels of circulating small non-coding RNAs
Analysis of relative quantitative of small non-coding RNAs
Each participant was enrolled to assess the of relative quantitative of small non-coding RNAs
Interventions
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Analysis of relative quantitative of small non-coding RNAs
Each participant was enrolled to assess the of relative quantitative of small non-coding RNAs
Eligibility Criteria
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Inclusion Criteria
* Age≥ 18 years old and ≤ 85 years old
* Histologically confirmed gastric cancer
Exclusion Criteria
* Surgery (excluding diagnostic biopsy) within 4 weeks prior to study
* Pregnancy or lactation period
* Legal incapacity
18 Years
85 Years
ALL
Yes
Sponsors
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Jiangsu Cancer Institute & Hospital
OTHER
The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu Province, China
OTHER
Affiliated Hospital of Nantong University
OTHER
Responsible Party
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Locations
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Affiliated Hospital of Nantong University
Nantong, Jiangsu, China
Countries
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Other Identifiers
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2023-L166
Identifier Type: -
Identifier Source: org_study_id
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