Genomics and Prognosis in GI Cancers

NCT ID: NCT05767697

Last Updated: 2024-03-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-04-15

Study Completion Date

2025-12-31

Brief Summary

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This study aims to collect biospecimens and explore the correlation of genomics and prognosis in alimentary tract cancers.

Detailed Description

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In this study, the investigators will collect clinical specimens of alimentary tract cancers and perform DNA and RNA analysis to identify genetic alterations for the development of a comprehensive somatic mutation databases and investigate their potential correlation with clinical, radiological and pathological variables. The genomics study included but not limited to target gene panel sequencing, whole exome sequencing, whole genome sequencing, bulk RNA sequencing, single cell RNA sequencing and metagenomics.

Conditions

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GI Cancer Liver Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Able to sign the informed consent
* Age \>= 20
* Histology proved pancreatic cancer, esophageal cancer, gastric cancer, hepatocellular carcinoma, cholangiocarcinoma, colorectal cancer
* Agree to provide tumor/normal tissue including but not limited to surgical specimen, biopsy, cytology specimen, bile, urine or stool
* Agree to receive blood sampling 20ml at first time and 10ml during each follow-up (total sampling amount no more than 30ml per month)

Exclusion Criteria

* Cannot cooperate with blood sampling
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cheng-Kung University Hospital

OTHER

Sponsor Role collaborator

National Health Research Institutes, Taiwan

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Li-Tzong Chen, MD PhD

Role: PRINCIPAL_INVESTIGATOR

National Health Research Institutes, Taiwan

Locations

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National Cheng-Kung University Hospital

Tainan City, , Taiwan

Site Status RECRUITING

National Institute of Cancer Research

Tainan City, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Yung-Yeh Su, MD

Role: CONTACT

+886-6-7000123 ext. 65181

Facility Contacts

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Yung-Yeh Su, MD

Role: primary

+886-6-7000123 ext. 65181

Yung-Yeh Su, MD

Role: primary

+8867-7000123 ext. 65181

Other Identifiers

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A-ER-109-073

Identifier Type: -

Identifier Source: org_study_id

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