Detection of CTC and ctDNA in the Diagnosis of Metastasis in Gastric Cancer

NCT ID: NCT05208372

Last Updated: 2022-01-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2024-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To investigate the value of CTCs and ctDNA in the diagnosis of metastasis in ascites/peritoneal flushing fluid and blood; To investigate the influence of laparoscopic CO2 pneumoperitoneum establishment on peritoneal and hematogenous metastasis of advanced gastric cancer; To explore the influence of the number and type of CTCs and ctDNA on metastasis and prognosis.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Stomach Neoplasms Metastasis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Laparotomy group

Patients who undergo radical laparotomy for gastric cancer.

CTC test

Intervention Type DIAGNOSTIC_TEST

Circulating tumor cells test of ascites and blood for patients with gastric cancer.

ctDNA test

Intervention Type DIAGNOSTIC_TEST

Circulating tumor DNA test of ascites and blood for patients with gastric cancer.

Laparoscopy group

Patients who undergo laparoscope-assisted radical gastrectomy for gastric cancer.

CTC test

Intervention Type DIAGNOSTIC_TEST

Circulating tumor cells test of ascites and blood for patients with gastric cancer.

ctDNA test

Intervention Type DIAGNOSTIC_TEST

Circulating tumor DNA test of ascites and blood for patients with gastric cancer.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

CTC test

Circulating tumor cells test of ascites and blood for patients with gastric cancer.

Intervention Type DIAGNOSTIC_TEST

ctDNA test

Circulating tumor DNA test of ascites and blood for patients with gastric cancer.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Patients who sign informed consent.
2. Gastric cancer is determined by more than 2 pathologists.
3. Patients with Borrmann III/IV gastric cancer.

Exclusion Criteria

1. Patients who complicate with other malignant tumors.
2. Patients who complicate with other serious heart and lung diseases.
3. Patients who receive preoperative neoadjuvant chemotherapy.
Minimum Eligible Age

18 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

First Hospital of China Medical University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Kai Li

Deputy Director of surgical Oncology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Kai Li, MD

Role: STUDY_DIRECTOR

First Hospital of China Medical University

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

First Hospital of Jinzhou Medical University

Jinzhou, Liaoning, China

Site Status RECRUITING

The First Affiliated Hospital of China Medical University

Shenyang, Liaoning, China

Site Status ACTIVE_NOT_RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

China

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Kai Li, MD

Role: CONTACT

8613998245233

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Yubin Wang

Role: primary

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

FirstHCMU_CTC_ctDNA

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.