Identification of Prognostic Gene Mutations in Biliary Tract Cancer Using Whole Genome Sequencing

NCT ID: NCT03718897

Last Updated: 2018-10-25

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-09-14
• Study Completion Date: 2022-09-02

Brief Summary

The purpose of this study is to investigate genetic mutations affecting prognosis using whole genome sequencing in patients with biliary tract cancer.

Detailed Description

Recently, as genome technology such as next-generation sequencing has progressed, precision medicine using genetic analysis in lung cancer, colorectal cancer, and melanoma has been actively studied. The need for such precision medicine is also increasing in biliary tract cancer patients. Although whole genome sequencing is relatively costly, it is known to provide more accurate information than other methods such as exome analysis and RNA sequencing in identifying promoter mutations, regulatory regions, and structural variants. Pancreatic cancer and melanoma have been studied by whole genome sequencing, but there is no previous study using whole genome sequencing method in biliary tract cancer.

Conditions

Biliary Tract Cancer

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

Endoscopic retrograde cholangiopancreatogram

Biopsy specimens are attained via endoscopic retrograde cholangiopancreatogram in patients with suspicious biliary tract cancer.

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Patients diagnosed with biliary tract cancer via endoscopic retrograde cholangiopancreatogram

Exclusion Criteria

• Pregnancy
• Other active tumors within 5 years
• Coagulopathy
• Severe mental illness

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Ji Kon Ryu

OTHER

Sponsor Role: lead

Responsible Party

Ji Kon Ryu

Professor

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Ji Kon Ryu, MD, phD

Role: STUDY_DIRECTOR

Seoul National University Hospital

Locations

Seoul National University Hospital

Seoul, , South Korea

Site Status: RECRUITING

Countries

South Korea

Central Contacts

Min su You, MD

Role: CONTACT

bass105@hanmail.net

82-2-2072-2228

Ji Kon Ryu, MD, phD

Role: CONTACT

jkryu@snu.ac.kr

82-2-2072-2228

Facility Contacts

Min su You, MD

Role: primary

bass105@hanmail.net

82-2-2072-2228

Ji Kon Ryu, MD, PhD

Role: backup

jkryu@snu.ac.kr

82-2-2072-2228

Other Identifiers

1808-056-964

Identifier Type: -

Identifier Source: org_study_id