Testing BRCA 1/2 Mutation Using Next Generation Sequencing

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

12 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-02-28

Study Completion Date

2015-02-28

Brief Summary

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Testing BRCA 1/2 mutation is important for patients with breast cancer, and Sanger sequencing is a standard method to identify BRCA 1/2 mutation. Next generation sequencing (NGS) is a high-throughput parallel sequencing that can provide genetic information with high accuracy. NGS is a faster and cost-effective method to detect gene mutations compared to Sanger sequencing. In this study, we evaluated the clinical role of NGS testing for BRCA 1/2 compared to Sanger sequencing.

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Detailed Description

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Conditions

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Breast Neoplasms Breast Cancer

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Sanger

BRCA 1/2 test results by Sanger sequencing

No interventions assigned to this group

NGS

BRCA 1/2 test results by NGS

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age \> 18
* Breast or ovarian cancer history in 2nd degree family members
* Male breast cancer
* Bilateral breast cancer
* Patient with breast cancer under 40 year of age
* Simultaneous breast and ovarian cancer
* Patients with epithelial ovarian cancer
* Breast cancer with other simultaneous extramammary malignancy