Effect of Adapted Physical Activity on Sleep Quality in People With Alcohol Use Disorder
NCT ID: NCT06706349
Last Updated: 2026-02-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
40 participants
INTERVENTIONAL
2024-10-17
2027-10-31
Brief Summary
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Participants will engage in APA sessions, complete sleep assessments (including sleep diaries and psychometric scales), and provide sociodemographic data and past activity adherence.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
SINGLE
Study Groups
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Managed adapted physical activity
Participants will receive 3 weekly sessions of supervised adapted physical activity (APA) starting from Visit 3.
APA managed by qualified instructor
Each session will be led by a qualified APA professional and will include a mix of aerobic, anaerobic, and 'mind-body' activities like yoga, tailored to participant preferences. Intensity will range from moderate to vigorous, with activities such as walking, cycling, and club-based exercises for at least 20 minutes per session. Participants will be progressively involved in session planning to support continued practice post-study. Heart rate monitoring will be used during exercises like the 6-minute walk test and chair rise test, while a daily activity calendar will help ensure adherence, documenting session dates, durations, subjective intensity, and activity type.
Autonomous adapted physical activity
Participants in this arm will receive a leaflet summarizing WHO recommendations on physical activity at the start of the study.
Autonomous APA
A leaflet highlighting the importance of non-sedentary behavior according to WHO recommendations will be provided to them. They will have the opportunity to engage in physical activity autonomously according to their preference.
Interventions
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APA managed by qualified instructor
Each session will be led by a qualified APA professional and will include a mix of aerobic, anaerobic, and 'mind-body' activities like yoga, tailored to participant preferences. Intensity will range from moderate to vigorous, with activities such as walking, cycling, and club-based exercises for at least 20 minutes per session. Participants will be progressively involved in session planning to support continued practice post-study. Heart rate monitoring will be used during exercises like the 6-minute walk test and chair rise test, while a daily activity calendar will help ensure adherence, documenting session dates, durations, subjective intensity, and activity type.
Autonomous APA
A leaflet highlighting the importance of non-sedentary behavior according to WHO recommendations will be provided to them. They will have the opportunity to engage in physical activity autonomously according to their preference.
Eligibility Criteria
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Inclusion Criteria
* Present an Alcohol Use Disorder (AUD) with at least 2 positive items as defined by the DSM-5
* Present a sleep complaint with a score on the Pittsburgh Sleep Quality Index (PSQI) ≥ 5
* Present active alcohol consumption with at least 6 days of excessive alcohol consumption in the last 4 weeks
* Speak and understand French
* Live within 30 minutes of the University Hospital of Besançon
* Treatment allowed if stabilized for at least 4 weeks
* Signature of informed consent indicating that the subject has understood the purpose and procedures required by the study and agrees to participate and comply with the requirements and restrictions inherent to the study
* Signed automobile safety contract:
1. The participant agrees to hand over the keys to their vehicle if necessary.
2. The keys will be returned when the blood alcohol level is below 0.25 mg/L
3. The participant agrees to name one or more people to contact in case the medical staff deems the participant unfit to return home alone.
* Affiliation to a French social security system or beneficiary of such a system
* Postmenopausal women for at least 24 months, surgically sterilized, or, for women of childbearing age, using an effective method of contraception (oral contraceptives, contraceptive injections, intrauterine devices, double-barrier method, contraceptive patches) (self-reported)
Exclusion Criteria
* Complex ventricular arrhythmias
* Severe uncontrolled hypertension
* Pulmonary hypertension (\>60 mmHg)
* Myocarditis or acute pericardial effusion
* Severe obstructive cardiomyopathy
* Severe and/or symptomatic aortic stenosis
* All acute illnesses
* All decompensated or unstable chronic conditions
* Significant malnutrition
* Extreme fatigue and/or manifest physical incapacity
* Severe anemia
* Severe intoxication (psychoactive substances)
* Severe withdrawal syndrome (Cushman \>7)
* Relative contraindications for high-intensity physical activities:
* Chronic respiratory insufficiency on long-term oxygen
* Severe chronic respiratory conditions
* Complicated diabetes with severe retinopathy
* Sickle cell disease
* Mild intoxication (psychoactive substances)
* Mild withdrawal syndrome (Cushman \>2)
* Musculoskeletal and dermatological limitations: Unhealed traumatic injuries.
* Musculoskeletal and dermatological limitations: Osteoarticular conditions in acute flare (osteoarthritis, arthritis).
* Musculoskeletal and dermatological limitations: Diabetes with plantar ulcer.
* Musculoskeletal and dermatological limitations: Pressure ulcers and evolving or chronic wounds.
* On the day of signing consent: Blood alcohol concentration \> 0 mg/L of expired air.
* On the day of signing consent: If blood alcohol concentration is \< 0.25 mg/L, the participant may join other therapeutic activities and return home autonomously.
* On the day of signing consent: If blood alcohol concentration is \> 0.25 mg/L without clinical signs of intoxication, the participant may join other therapeutic activities and return home accompanied.
* On the day of signing consent: If blood alcohol concentration is \> 0.25 mg/L with clinical signs of intoxication, the participant will not join other therapeutic activities. A supervised room placement will be offered, and emergency services may be contacted if intoxication is unusually high (\>2 g/L).
* Excessive alcohol consumption ≥ 6 days in the 4 weeks prior to inclusion.
* Average alcohol consumption \> 20 g/day or \> 100 g/week.
* CIWA score ≥ 9, indicating the need for medication-assisted withdrawal.
* High physical activity levels according to the Global Physical Activity Questionnaire (GPAQ).
* Concurrent treatment with disulfiram, melatonin, and beta-blockers.
* Unstable or recently changed treatments (\<4 weeks).
* History of pre-delirium tremens or delirium tremens.
* Substance use disorder (other than alcohol/nicotine per DSM-5).
* Acute psychiatric disorders requiring immediate hospitalization or adjustment of psychotropic medications.
* Advanced somatic disorders contraindicating physical activity.
* Lack of signed automobile safety contract.
* Legal incapacity or refusal to sign consent.
* No health insurance.
* Anticipated poor cooperation or difficulty completing the study
* Pregnant or breastfeeding women.
* Currently in the exclusion period of another study or listed in the national volunteer registry.
18 Years
65 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire de Besancon
OTHER
Responsible Party
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Principal Investigators
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Julie GIUSTINIANI, MD
Role: PRINCIPAL_INVESTIGATOR
CHU Besançon
Locations
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CHU de Besançon
Besançon, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2024/863
Identifier Type: -
Identifier Source: org_study_id
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