High Interval Versus Moderate Intensity Continuous Training on Soluble st2 Biomarkers in Chronic Heart Failure

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-15

Study Completion Date

2023-10-16

Brief Summary

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This study was designed to compare between the effect of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on soluble ST2 biomarkers among chronic heart failure patients, also measure the improvement in the quality of life with different modes of exercise and with of it is more benifitial for the heart failure patient

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Detailed Description

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The data concerned with the study including soluble ST2 biomarker levels, ejection fraction and MLHFQ was measured before and after twelve weeks of treatment.In this study a total sixty male patients with chronic heart failure NYHA class (I \&II) were selected from the outpatient clinic, El-Demerdash hospital, Ain-shams University. Their age ranged from 50-60 years. Patients were randomly assigned into two groups, group A receiving HIIT along with prescribed medical treatment and group B receiving MCT along with prescribed medical treatment.

Conditions

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Heart Failure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

1. Patients will receive high intensity interval training (HIIT)
2. Patients will receive moderate intensity continuous training (MICT)

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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group A

high intensity interval training

Group Type EXPERIMENTAL

HIITS

Intervention Type OTHER

Frequency: HIIT will be in 2 supervised sessions per week for 12 weeks on the treadmill.

session duration from 30-40 min including the waming up and cooling down Intensity: HIIT included 4 minute intervals aiming 60-85% of heart rate reserve

group B

moderate intensity continuous training

Group Type EXPERIMENTAL

MICT

Intervention Type OTHER

Frequency: Moderate continuous training is scheduled 2 times per week for 12 weeks.

Intensity: exercise had been applied on the treadmill with 40%-59% of heart rate reserve) session duration from 30-40 min including the warming up and cooling down

Interventions

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HIITS

Frequency: HIIT will be in 2 supervised sessions per week for 12 weeks on the treadmill.

session duration from 30-40 min including the waming up and cooling down Intensity: HIIT included 4 minute intervals aiming 60-85% of heart rate reserve

Intervention Type OTHER

MICT

Frequency: Moderate continuous training is scheduled 2 times per week for 12 weeks.

Intensity: exercise had been applied on the treadmill with 40%-59% of heart rate reserve) session duration from 30-40 min including the warming up and cooling down

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* The patients selection was according to the following criteria:

* Patients diagnosed with chronic heart failure (New York heart association class I\& II) with systolic left ventricular dysfunction.
* Their left ventricular ejection fraction (LVEF) \<40%.
* Medical treatment was optimized at least three months prior to study entry.
* All patients didn't participate in any rehabilitation programs prior to the study.

Exclusion Criteria

* Patients who had met one of the following criteria were excluded from the study:

1. Signs of acute heart failure, unstable angina or severe arrhythmia three months prior to enrolment in the study.
2. Pacemakers.
3. Chronic obstructive pulmonary disease.
4. Other disorders counteracting exercise testing conditions that limit lower limb mobility (for example, burns, fractures)
5. Pre-existing neuromuscular diseases (for example Myasthenia Gravis).

Minimum Eligible Age

50 Years

Maximum Eligible Age

60 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No