CWT Versus AT on Selected Cardiovascular Indices and Functional Capacity in Patients With Ischemic Cardiomyopathy.

NCT ID: NCT05674955

Last Updated: 2025-07-10

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-08-25
• Study Completion Date: 2024-10-25

Brief Summary

To compare between the effect of circuit weight and aerobic training on selected cardiovascular indices and functional capacity in patients with ischemic cardiomyopathy.

Detailed Description

Ischemic cardiomyopathy (ICM) is a term that refers to the heart's decreased ability to pump blood properly due to myocardial damage brought upon by ischemia. Ischemic cardiomyopathy has a spectrum of clinical changes which eventually leads to congestive heart failure (CHF). Initially, there is a reversible loss of cardiac contractile function because of decreased oxygen supply to the heart muscle; however, when there is ischemia for a prolonged period, there is irreversible cardiac muscle damage resulting in cardiac remodeling. Remodeling is primarily achieved by myocardial fibrosis which results in decreased cardiac function, arrhythmia, and possible cardiac conduction system impairment. In ischemic cardiomyopathy, there is a significant impairment of the left ventricular systolic function, with a left ventricular ejection fraction (LVEF) less than 40% (Bhandari et al., 2021).

Conditions

Ischemic Cardiomyopathy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Circuit weight group

Group Type: EXPERIMENTAL

Circuit weight versus aerobic training

Intervention Type: DIAGNOSTIC_TEST

Circuit weight :Duration: 30 min-60 min (total session) Frequency: 3 times / week. Intensity: increased load was established when subject was able to complete 12 repetitions ( Wayne, 2014)

B- Aerobic training:

This mode of exercise will be conducted for study group B as follows:

Intensity: started by 60-85% of target heart rate according to each patient response Target heart rate (THR) = 60% -85% (maximum heart rate-resting heart rate) + resting heart rate Maximum heart rate (MHR) = (220-Age). Mode: Walking on treadmill. Duration: Each session consisted of 10 minutes warming up firstly then 30 minutes time of session ended by 10 minutes cool down exercises.

Frequency: Three times / week (Nishi et al., 2011).

C-Traditional medical treatment:

This treatment will be conducted for all group A, B and C.

Aerobic group

Group Type: EXPERIMENTAL

Circuit weight versus aerobic training

Intervention Type: DIAGNOSTIC_TEST

Circuit weight :Duration: 30 min-60 min (total session) Frequency: 3 times / week. Intensity: increased load was established when subject was able to complete 12 repetitions ( Wayne, 2014)

B- Aerobic training:

This mode of exercise will be conducted for study group B as follows:

Intensity: started by 60-85% of target heart rate according to each patient response Target heart rate (THR) = 60% -85% (maximum heart rate-resting heart rate) + resting heart rate Maximum heart rate (MHR) = (220-Age). Mode: Walking on treadmill. Duration: Each session consisted of 10 minutes warming up firstly then 30 minutes time of session ended by 10 minutes cool down exercises.

Frequency: Three times / week (Nishi et al., 2011).

C-Traditional medical treatment:

This treatment will be conducted for all group A, B and C.

Control Group

Group Type: EXPERIMENTAL

Circuit weight versus aerobic training

Intervention Type: DIAGNOSTIC_TEST

Circuit weight :Duration: 30 min-60 min (total session) Frequency: 3 times / week. Intensity: increased load was established when subject was able to complete 12 repetitions ( Wayne, 2014)

B- Aerobic training:

This mode of exercise will be conducted for study group B as follows:

Intensity: started by 60-85% of target heart rate according to each patient response Target heart rate (THR) = 60% -85% (maximum heart rate-resting heart rate) + resting heart rate Maximum heart rate (MHR) = (220-Age). Mode: Walking on treadmill. Duration: Each session consisted of 10 minutes warming up firstly then 30 minutes time of session ended by 10 minutes cool down exercises.

Frequency: Three times / week (Nishi et al., 2011).

C-Traditional medical treatment:

This treatment will be conducted for all group A, B and C.

Interventions

Circuit weight versus aerobic training

Circuit weight :Duration: 30 min-60 min (total session) Frequency: 3 times / week. Intensity: increased load was established when subject was able to complete 12 repetitions ( Wayne, 2014)

B- Aerobic training:

This mode of exercise will be conducted for study group B as follows:

Intensity: started by 60-85% of target heart rate according to each patient response Target heart rate (THR) = 60% -85% (maximum heart rate-resting heart rate) + resting heart rate Maximum heart rate (MHR) = (220-Age). Mode: Walking on treadmill. Duration: Each session consisted of 10 minutes warming up firstly then 30 minutes time of session ended by 10 minutes cool down exercises.

Frequency: Three times / week (Nishi et al., 2011).

C-Traditional medical treatment:

This treatment will be conducted for all group A, B and C.

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Sixty male patients with ischemic cardiomyopathy as a result of a recent acute myocardial infarction event (≤2 months) with 40%<LVEF<50%.
• They are functionally classified as class II according to New York Heart Association (NYHA).
• Their age will be ranged from 45 to 55 years old.
• Their BMI will be ranged from 25 to 29.9 kg/m².
• They will have good mentality.

Exclusion Criteria

• Recurrent coronary heart disease.
• Severe valvular diseases.
• Underlying pulmonary disease (aspiration pneumonia, chronic obstructive pulmonary disease, pneumothorax, etc.).
• Inability to ambulate owing to physical problems (paresis induced by cerebral stroke, spinal cord injury, amputation, severe pain, dyspnea, etc.).
• muskloskletal problems (e.g. severe osteoarthritis or ankylosing spondylitis).
• Impaired cognitive function (vascular dementia, Alzheimer's dementia, other psychological disease, etc.)

• Minimum Eligible Age: 45 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

Cairo University

OTHER

Sponsor Role: lead

Responsible Party

Samira Shukrey Shaffik Eshak

Domenstrator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Cairo University

Giza, , Egypt

Countries

Egypt

References

Nishi I, Noguchi T, Iwanaga Y, Furuichi S, Aihara N, Takaki H, Goto Y. Effects of exercise training in patients with chronic heart failure and advanced left ventricular systolic dysfunction receiving beta-blockers. Circ J. 2011;75(7):1649-55. doi: 10.1253/circj.cj-10-0899. Epub 2011 May 25.

Reference Type: BACKGROUND

PMID: 21613745 (View on PubMed)

Other Identifiers

Cw versus AT in cardiomyopathy

Identifier Type: -

Identifier Source: org_study_id